期刊
JOURNAL OF POLYMER SCIENCE
卷 59, 期 15, 页码 1610-1642出版社
WILEY
DOI: 10.1002/pol.20210251
关键词
chitosan; nanocomposites; nanoparticles; regenerative medicines and drug delivery
资金
- Alexander von Humboldt (AvH) Foundation for the postdoctoral fellowship
Chitosan, a biobased polymer, is gaining attention for its outstanding physico-chemical characteristics. Recent research shows its diverse applications in agricultural, biomedical, and bioimaging fields. Chitosan nanoparticles have demonstrated superior biological activity in regenerative medicine, wound dressings, drug delivery, and biosensing applications.
Chitosan as a biobased polymer is gaining increasing attention due to its extraordinary physico-chemical characteristics and properties. While a primary use of chitosan has been in horticultural and agricultural applications for plant defense and to increase crop yield, recent research reports display various new utilizations in the field of advanced biomedical devices, targeted drug delivery, and as bioimaging sensors. Chitosan possesses multiple characteristics such as antimicrobial properties, stimuli-responsiveness, tunable mechanical strength, biocompatibility, biodegradability, and water-solubility. Further, chitosan can be processed into nanoparticles, nano-vehicles, nanocapsules, scaffolds, fiber meshes, and 3D printed scaffolds for a variety of applications. In recent times, nanoparticles incorporated in chitosan matrices have been identified to show superior biological activity, as cells tend to proliferate/differentiate faster when they interact with nanocomposites rather than bulk or micron size substrates/scaffolds. The present article intents to cover chitosan-based nanocomposites used for regenerative medicine, wound dressings, drug delivery, and biosensing applications.
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