期刊
ACS APPLIED POLYMER MATERIALS
卷 3, 期 9, 页码 4375-4389出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsapm.1c00695
关键词
semiconducting polymer nanoparticles; activatable nanomedicines; phototherapy; internal stimuli; photoactivation
资金
- Singapore Ministry of Education [2019-T1-002-045, RG125/19 (S), RT05/20, MOE2018-T2-2042]
- A* STAR SERC AME Programmatic Fund [SERC A18A8b0059]
Semiconducting polymer nanoparticle (SPN) based activatable nanomedicines utilize ideal optical properties to release therapeutic agents at tumor sites, reducing off-target probabilities and enhancing biosafety.
Phototherapy including photodynamic therapy and photothermal therapy provides an alternative pathway for cancer therapy. However, single-mode phototherapy suffers from low therapeutic efficiency; therefore, other therapeutic modalities are often combined to enhance the antitumor effect. In this review, we summarize the recent progress of semiconducting polymer nanoparticle (SPN) based activatable nanomedicines for combinational cancer therapy. With ideal optical properties, SPNs function not only as drug carriers but also as phototherapeutic agents (photodynamic or photothermal). Under the internal (such as acidic pH, ROS, and hypoxia) or external stimuli (such as light), SPN-based activatable nanomedicines can be specifically activated to release therapeutic agents at tumor sites, which reduces off-target probabilities and thus enhances the biosafety of the nanomedicine.
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