期刊
ACS APPLIED POLYMER MATERIALS
卷 3, 期 8, 页码 3831-3842出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsapm.1c00411
关键词
backbone-degradable; light-responsive; redox-responsive; drug delivery; nanoparticles
资金
- Deutsche Forschungsgemeinschaft (Paderborn University) [397670170]
The study synthesized a series of light-responsive polymers that can degrade rapidly in solution, enabling precise drug release and improved therapeutic effects.
In modern therapy, cutting side effects caused by the administration of drugs is one of the core challenges. One possible strategy is the delivery of a drug to the disease site by encapsulation into a polymeric matrix. Especially, light-responsive polymers are regarded as promising materials due to, e.g., the capability of tailored on-demand release in illuminated areas. In this work, a series of light-responsive backbone-degradable (co-)polymers were synthesized by polycondensation and polyaddition. All obtained polymers showed rapid degradation in solution upon exposure to ultraviolet (UV) light as observed by size-exclusion chromatography (SEC) and ultraviolet-visible (UV-vis) spectroscopy. Light-induced decomposition of films prepared from the polycarbonate was confirmed by UV-vis, surface plasmon resonance (SPR), and profilometry measurements. Depending on the incorporated comonomers, the functional co-polyurethanes exhibited either enhanced hydrophilicity or dual-responsiveness to light and redox environments, which was detected by SEC after treatment with a reducing agent. The formulation of nanoparticles from light-responsive polyurethanes proved the processability of the synthesized polymers, and dynamic light scattering (DLS) measurements confirmed the photo-induced degradation of the prepared particles. Water-soluble tetrazolium salt (WST-1) assays were carried out to evaluate the cytotoxic potential before and after irradiation.
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