4.4 Review

Vitamin D receptor gene polymorphisms in atopy

期刊

IMMUNITY INFLAMMATION AND DISEASE
卷 9, 期 4, 页码 1153-1159

出版社

WILEY
DOI: 10.1002/iid3.487

关键词

atopy; VDR; vitamin D

资金

  1. Mutual Funds of the Latvia-Lithuania-Taiwan Cooperation Project [P-LLT-20-4]

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The role of vitamin D levels and vitamin D receptor gene polymorphisms in atopy is a topic of interest, but there is still no conclusive data and results from studies are inconsistent. Despite the controversy, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases.
Background: The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. Aims: This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy. Methods & Materials: We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients. Results: We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti-inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial. Discussion: The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma. Conclusions: There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.

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