期刊
LIFE SCIENCE ALLIANCE
卷 4, 期 10, 页码 -出版社
LIFE SCIENCE ALLIANCE LLC
DOI: 10.26508/lsa.202101056
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资金
- National Institutes of Health [R01-AI089805, R01-CA225028, T32-AI007363]
- BurroughsWellcome Fund, Big Data in the Life Sciences Training Program
- Air Force Office of Scientific Research [FA9550-18-1-0017, P30-CA023108]
Dendritic cells play a crucial role in supporting T-RM responses to melanoma, with their close interaction being essential for maintaining immune protection. Chemotaxis and adhesion mediated by the CXCR6/CXCL16 axis are critical for T-RM migration and persistence in the skin, with the interaction between CXCR6-expressing T-RM cells and CXCL16-expressing APCs being pivotal for sustaining T-RM cell-mediated tumor protection.
Tissue-resident memory (T-RM) T cells are emerging as critical components of the immune response to cancer; yet, requirements for their ongoing function and maintenance remain unclear. APCs promote T-RM cell differentiation and re-activation but have not been implicated in sustaining T-RM cell responses. Here, we identified a novel role for dendritic cells in supporting T-RM to melanoma. We showed that CD8 T-RM cells remain in close proximity to dendritic cells in the skin. Depletion of CD11c(+) cells results in rapid disaggregation and eventual loss of melanoma-specific T-RM cells. In addition, we determined that T-RM migration and/or persistence requires chemotaxis and adhesion mediated by the CXCR6/CXCL16 axis. The interaction between CXCR6-expressing T-RM cells and CXCL16-expressing APCs was found to be critical for sustaining T-RM cell-mediated tumor protection. These findings substantially expand our knowledge of APC functions in T-RM T-cell homeostasis and longevity.
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