期刊
LIFE-BASEL
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/life11090959
关键词
body temperature maintenance; cold adaptation; cattle; whole-genome resequencing
资金
- Russian Science Foundation grant (RSF) [19-76-20026]
- Russian Science Foundation [19-76-20026] Funding Source: Russian Science Foundation
Using whole-genome resequencing of animals showing contrasting phenotypes on temperature maintenance under acute cold stress and existing SNP functional annotations, this study identified chromosomal regions and candidate SNPs controlling body temperature in Siberian cattle populations. The research highlighted multiple candidate genes related to thermal adaptations in cattle and provided insights for cattle breeding strategies in harsh climates, including the Russian Federation.
Despite the economic importance of creating cold resilient cattle breeds, our knowledge of the genetic basis of adaptation to cold environments in cattle is still scarce compared to information on other economically important traits. Herein, using whole-genome resequencing of animals showing contrasting phenotypes on temperature maintenance under acute cold stress combined with the existing SNP (single nucleotide polymorphism) functional annotations, we report chromosomal regions and candidate SNPs controlling body temperature in the Siberian cattle populations. The SNP ranking procedure based on regional F-ST calculations, functional annotations, and the allele frequency difference between cold-tolerant and cold-sensitive groups of animals pointed to multiple candidate genes. Among these, GRIA4, COX17, MAATS1, UPK1B, IFNGR1, DDX23, PPT1, THBS1, CCL5, ATF1, PLA1A, PRKAG1, and NR1I2 were previously related to thermal adaptations in cattle. Other genes, for example KMT2D and SNRPA1, are known to be related to thermogenesis in mice and cold adaptation in common carp, respectively. This work could be useful for cattle breeding strategies in countries with harsh climates, including the Russian Federation.
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