期刊
LIFE-BASEL
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/life11070672
关键词
oxidative stress; cardiovascular diseases; metabolic disorders; adipose tissue; hypothalamic dysfunction
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [374031971-TRR 240]
- DZHK (German Research Centre for Cardiovascular Research)
- ERA-CVD [ERAPERMED2020-245]
Cardiovascular diseases are the main cause of death globally, with oxidative stress and inflammation playing important roles in their progression. Natural antioxidant strategies are increasingly being discovered, and new treatment strategies focusing on modulating oxidative stress are under investigation.
Cardiovascular diseases (CVD) constitute the main cause of death worldwide. Both inflammation and oxidative stress have been reported to be involved in the progress of CVD. It is well known that generation of oxidative stress during the course of CVD is involved in tissue damage and inflammation, causing deleterious effects such as hypertension, dysfunctional metabolism, endothelial dysfunction, stroke, and myocardial infarction. Remarkably, natural antioxidant strategies have been increasingly discovered and are subject to current scientific investigations. Here, we addressed the activation of immune cells in the context of ROS production, as well as how their interaction with other cellular players and further (immune) mediators contribute to metabolic and cardiovascular disorders. We also highlight how a dysregulated complement system contributes to immune imbalance and tissue damage in the context of increases oxidative stress. Additionally, modulation of hypothalamic oxidative stress is discussed, which may offer novel treatment strategies for type-2 diabetes and obesity. Together, we provide new perspectives on therapy strategies for CVD caused by oxidative stress, with a focus on oxidative stress.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据