期刊
LIFE-BASEL
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/life11060526
关键词
autophagy; protein structure; drug discovery
资金
- Basic Science Research Program through the National Research Foundation of Korea(NRF) - Ministry of Education [2019R1A6A1A10072987]
Autophagy, a lysosome-dependent intracellular degradation machinery, is crucial in regulating cellular homeostasis and is associated with various diseases. Recent structural studies and discovery of modulators have identified targeting autophagy as a promising strategy for novel drug development.
Autophagy is a lysosome-dependent intracellular degradation machinery that plays an essential role in the regulation of cellular homeostasis. As many studies have revealed that autophagy is related to cancer, neurodegenerative diseases, metabolic diseases, and so on, and it is considered as a promising drug target. Recent advances in structural determination and computational technologies provide important structural information on essential autophagy-related proteins. Combined with high-throughput screening methods, structure-activity relationship studies have led to the discovery of molecules that modulate autophagy. In this review, we summarize the recent structural studies on autophagy-related proteins and the discovery of modulators, indicating that targeting autophagy can be utilized as an effective strategy for novel drug development.
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