Screening, Diagnostic and Prognostic Tests for COVID-19: A Comprehensive Review

While molecular testing with real-time polymerase chain reaction (RT-PCR) remains the gold-standard test for COVID-19 diagnosis and screening, more rapid or affordable molecular and antigen testing options have been developed. More affordable, point-of-care antigen testing, despite being less sensitive compared to molecular assays, might be preferable for wider screening initiatives. Simple laboratory, imaging and clinical parameters could facilitate prognostication and triage. This comprehensive review summarises current evidence on the diagnostic, screening and prognostic tests for COVID-19.

Automated summary

RT-PCR remains the gold standard for COVID-19 diagnosis, but more rapid or affordable testing options have been developed. Antigen testing, while less sensitive than molecular assays, may be preferable for wider screening initiatives. Simple parameters can facilitate prognostication and triage.