Machine Learning Protocols in Early Cancer Detection Based on Liquid Biopsy: A Survey

With the advances of liquid biopsy technology, there is increasing evidence that body fluid such as blood, urine, and saliva could harbor the potential biomarkers associated with tumor origin. Traditional correlation analysis methods are no longer sufficient to capture the high-resolution complex relationships between biomarkers and cancer subtype heterogeneity. To address the challenge, researchers proposed machine learning techniques with liquid biopsy data to explore the essence of tumor origin together. In this survey, we review the machine learning protocols and provide corresponding code demos for the approaches mentioned. We discuss algorithmic principles and frameworks extensively developed to reveal cancer mechanisms and consider the future prospects in biomarker exploration and cancer diagnostics.

Automated summary

With the advancements in liquid biopsy technology, increasing attention has been paid to the potential biomarkers in body fluids and their relationship with tumor origin. Traditional correlation analysis methods are no longer applicable, and machine learning has become an important tool in exploring the essence of tumor origin.