期刊
MEMBRANES
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/membranes11070486
关键词
GABA(A) receptors; L-type voltage-gated calcium channels; transcription; phosphorylation; trafficking; clustering
类别
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina) [11220130100266]
GABA(A) receptors are pentameric ion channels crucial for inhibitory transmissions in the central nervous system, with their function regulated by various factors such as receptor subtypes and calcium channels. Dysfunctional alterations of these receptors are associated with neuropsychiatric disorders and influence their plasticity.
GABA(A) receptors are pentameric ion channels that mediate most synaptic and tonic extrasynaptic inhibitory transmissions in the central nervous system. There are multiple GABA(A) receptor subtypes constructed from 19 different subunits in mammals that exhibit different regional and subcellular distributions and distinct pharmacological properties. Dysfunctional alterations of GABA(A) receptors are associated with various neuropsychiatric disorders. Short- and long-term plastic changes in GABA(A) receptors can be induced by the activation of different intracellular signaling pathways that are triggered, under physiological and pathological conditions, by calcium entering through voltage-gated calcium channels. This review discusses several mechanisms of regulation of GABA(A) receptor function that result from the activation of L-type voltage gated calcium channels. Calcium influx via these channels activates different signaling cascades that lead to changes in GABA(A) receptor transcription, phosphorylation, trafficking, and synaptic clustering, thus regulating the inhibitory synaptic strength. These plastic mechanisms regulate the interplay of synaptic excitation and inhibition that is crucial for the normal function of neuronal circuits.
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