期刊
CHEMOSENSORS
卷 9, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/chemosensors9080191
关键词
carbon dots; pH sensing; active surface preservation; nanosensor; fluorescence; biocompatibility
资金
- Portuguese Foundation for Science and Technology, FCT [UIDB/00081/2020, UIDB/05748/2020, PTDC/QUI-QFI/2870/2020]
- Portuguese Foundation for Science and Technology (FCT), under the Scientific Employment Stimulus [CEECIND/01425/2017]
- FCT [UIDB/4255/2020, IF/00092/2014/CP1255/CT0004]
- Spanish Ministerio de Economia, Industria y Competividad [RTI2018-099668-BC22]
In this study, a carbon dot-based fluorescent pH nanosensor was developed rationally using an active surface preservation strategy to retain fluorescein-like structures. The obtained nanoparticles demonstrated sensitive and selective pH detection, with fluorescence reversibility, photostability, and compatibility with human cell lines, showcasing potential applications in pH determination without the need for post-synthesis functionalization strategies.
Here we report the rational development of a carbon dot (CDs)-based fluorescent pH nanosensor by employing an active surface preservation strategy. More specifically, citric acid, urea and fluorescein were subjected to a one-pot hydrothermal treatment, which preserved fluorescein-like structures on the surface of the CDs. The obtained CDs showed pH-sensitive green emission, which can be used to determine pH variations from 3.7 to 12.1 by fluorescence enhancement. Moreover, the obtained nanoparticles showed excellent selectivity toward pH, fluorescence reversibility in different pH values, photostability, while being compatible with human cell lines (even at high concentrations). Furthermore, their performance as pH sensors was comparable with reference pH determination procedures. Thus, an active surface preservation strategy was successfully employed to develop fluorescence pH nanosensors in a rational manner and without post-synthesis functionalization strategies, which show potential for future use in pH determination.
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