期刊
BIOSENSORS-BASEL
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/bios11070214
关键词
nanopore technology; nanopore sequencing; diagnosis of cancer; biosensor
资金
- National Science Foundation, China [61971410, 62001458]
- Shanghai Engineer & Technology Research Center of Internet of Things for Respiratory Medicine [20DZ2254400]
Nanopore technology has become increasingly important in the field of life science and biomedical research, particularly in gene sequencing and biomolecular studies, showing promising applications in cancer diagnosis, virus detection, genome assembly, and other biomedical sensing fields.
In recent years, nanopore technology has become increasingly important in the field of life science and biomedical research. By embedding a nano-scale hole in a thin membrane and measuring the electrochemical signal, nanopore technology can be used to investigate the nucleic acids and other biomacromolecules. One of the most successful applications of nanopore technology, the Oxford Nanopore Technology, marks the beginning of the fourth generation of gene sequencing technology. In this review, the operational principle and the technology for signal processing of the nanopore gene sequencing are documented. Moreover, this review focuses on the applications using nanopore gene sequencing technology, including the diagnosis of cancer, detection of viruses and other microbes, and the assembly of genomes. These applications show that nanopore technology is promising in the field of biological and biomedical sensing.
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