期刊
BIOSENSORS-BASEL
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/bios11080281
关键词
circulating tumor cells; cancer biomarkers; electrochemical biosensors; optical biosensors; nanomaterials
资金
- Program for Innovative Research Team of Science and Technology in the University of Henan Province [21IRTSTHN005]
- National Natural Science Foundation of China [21905002]
This review summarizes the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, aiming at amplifying the signal and enhancing the sensitivity.
The accurate analysis of circulating tumor cells (CTCs) holds great promise in early diagnosis and prognosis of cancers. However, the extremely low abundance of CTCs in peripheral blood samples limits the practical utility of the traditional methods for CTCs detection. Thus, novel and powerful strategies have been proposed for sensitive detection of CTCs. In particular, nanomaterials with exceptional physical and chemical properties have been used to fabricate cytosensors for amplifying the signal and enhancing the sensitivity. In this review, we summarize the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, including fluorescence, colorimetry, surface-enhanced Raman scattering, chemiluminescence, electrochemistry, electrochemiluminescence, photoelectrochemistry and so on.
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