期刊
FRONTIERS IN NUTRITION
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2021.718356
关键词
intestinal epithelial barrier; mucosal immune system; gut microbiota; IBS; IBD; celiac disease; non-celiac gluten sensitivity
资金
- Italian Ministry of Education, University and Research and funds from the University of Bologna (RFO)
- european grant HORIZON 2020-SC1-BHC-2018-2020/H2020-SC1-2019-Two-Stage-RTD-DISCOVERIE PROJECT
- Fondazione del Monte di Bologna e Ravenna
- Fondazione Carisbo, Bologna, Italy
- Italian Ministry of Health [GR-2018-12367062]
The intestinal epithelial barrier plays a crucial role in maintaining homeostasis by controlling the passage of nutrients and harmful substances. Tight junctions are responsible for regulating paracellular permeability and maintaining barrier integrity. Factors like cytokines, gut microbiota, and dietary components influence the function of intestinal TJs, highlighting their importance in various diseases such as IBS, IBD, and gluten-related conditions.
The intestinal epithelial barrier (IEB) is one of the largest interfaces between the environment and the internal milieu of the body. It is essential to limit the passage of harmful antigens and microorganisms and, on the other side, to assure the absorption of nutrients and water. The maintenance of this delicate equilibrium is tightly regulated as it is essential for human homeostasis. Luminal solutes and ions can pass across the IEB via two main routes: the transcellular pathway or the paracellular pathway. Tight junctions (TJs) are a multi-protein complex responsible for the regulation of paracellular permeability. TJs control the passage of antigens through the IEB and have a key role in maintaining barrier integrity. Several factors, including cytokines, gut microbiota, and dietary components are known to regulate intestinal TJs. Gut microbiota participates in several human functions including the modulation of epithelial cells and immune system through the release of several metabolites, such as short-chain fatty acids (SCFAs). Mediators released by immune cells can induce epithelial cell damage and TJs dysfunction. The subsequent disruption of the IEB allows the passage of antigens into the mucosa leading to further inflammation. Growing evidence indicates that dysbiosis, immune activation, and IEB dysfunction have a role in several diseases, including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gluten-related conditions. Here we summarize the interplay between the IEB and gut microbiota and mucosal immune system and their involvement in IBS, IBD, and gluten-related disorders.
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