期刊
ENEURO
卷 8, 期 4, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/ENEURO.0102-21.2021
关键词
cortico-cortical connections; diffusion tractography; frontal cortex; intraparietal sulcus; macaque brain; parietal cortex
资金
- Ministero dell'Istruzione, dell'UNiversita e della Ricerca of Italy [201794KEER_002, 2017KZNZLN_002]
- Istituto Italiano di Tecnologia
- Lausanne University Hospital (CHUV)
- University of Lausanne (UNIL)
- Ecole Polytechnique Federale de Lausanne (EPFL)
- University of Geneva (UNIGE)
- Geneva University Hospitals (HUG)
In macaque monkeys, the dorsal bank of the intraparietal sulcus (db-IPS) can be subdivided into a rostral intraparietal area PEip, projecting to the spinal cord, and a caudal medial intraparietal area MIP lacking such projections.
In macaque monkeys, dorsal intraparietal areas are involved in several daily visuomotor actions. However, their border and sources of cortical afferents remain loosely defined. Combining retrograde histologic tracing and MRI diffusion-based tractography, we found a complex hodology of the dorsal bank of the intraparietal sulcus (db-IPS), which can be subdivided into a rostral intraparietal area PEip, projecting to the spinal cord, and a caudal medial intraparietal area MIP lacking such projections. Both include an anterior and a posterior sector, emerging from their ipsilateral, gradient-like connectivity profiles. As tractography estimations, we used the cross-sectional area of the white matter bundles connecting each area with other parietal and frontal regions, after selecting regions of interest (ROIs) corresponding to the injection sites of neural tracers. For most connections, we found a significant correlation between the proportions of cells projecting to all sectors of PEip and MIP along the continuum of the db-IPS and tractography. The latter also revealed false positive but plausible connections awaiting histologic validation.
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