期刊
WORLD JOURNAL OF PSYCHIATRY
卷 11, 期 7, 页码 347-354出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.5498/wjp.v11.i7.347
关键词
COVID-19; Immunological mechanism; Neuropsychiatric manifestation; Cytokine storm; Adaptive immune response; Innate immune response
类别
There is a variable expression of clinical neurological manifestations in patients with COVID-19, including symptoms like fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headache. Neuropsychiatric disorders associated with COVID-19 show exacerbation with symptoms such as depression, anxiety, mood alterations, psychosis, post-traumatic stress disorder, delirium, and cognitive impairment. The involvement of the immune system in the pathological mechanism of COVID-19 and its impact on mental health disorders is suggested.
Evolving data show a variable expression of clinical neurological manifestations in patients suffering with coronavirus disease 2019 (COVID-19) from early disease onset. The most frequent symptoms and signs are fatigue, dizziness, impaired consciousness, ageusia, anosmia, radicular pain, and headache, as well as others. Based on the high number of series of cases reported, there is evidence for the implication of the immune system in the pathological mechanism of COVID-19. Although the exact role of the immunological mechanism is not elucidated, two main mechanisms are suggested which implicate the direct effect of severe acute respiratory syndrome coronavirus 2 infection in the central nervous system and neuroinflammation. In the context of neurological manifestations associated with COVID-19, neuropsychiatric disorders show an exacerbation and are described by symptoms and signs such as depression, anxiety, mood alterations, psychosis, post-traumatic stress disorder, delirium, and cognitive impairment, which appear to be common in COVID-19 survivors. A worsened score on psychopathological measures is seen in those with a history of psychiatric comorbidities. We review the neuropsychiatric manifestations associated with COVID-19 and some critical aspects of the innate and adaptive immune system involved in mental health disorders occurring in COVID-19.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据