期刊
BIOLOGY-BASEL
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/biology10080712
关键词
RNA binding protein; hnRNP A; B; RNA metabolism; splicing; RNA trafficking; RNA granules; RNA homeostasis; telomeres; neurodegenerative disease
类别
资金
- Government of Canada's New Frontiers in Research Fund (NFRF) [NFRFE-2020-00924]
The hnRNP A/B family of proteins, consisting of A1, A2/B1, A3, and A0, play a significant role in regulating cellular RNAs. While A1 and A2/B1 are extensively studied, the functions of A0 and A3 proteins are lesser known. Further research is needed on the regulation, distribution, and different isoforms of these proteins to better understand their role in cell function and disease.
Simple Summary The hnRNP A/B family of proteins (comprised of A1, A2/B1, A3, and A0) contributes to the regulation of the majority of cellular RNAs. Here, we provide a comprehensive overview of what is known of each protein's functions, highlighting important differences between them. While there is extensive information about A1 and A2/B1, we found that even the basic functions of the A0 and A3 proteins have not been well-studied. We also noted that the regulation and tissue distribution of all four of the proteins and their different isoforms require further study. Finally, since these proteins together play such a central role in regulating the cell's RNA, we call for careful comparative examination of these proteins to better define the precise boundaries of each protein's role in cell function and disease. The hnRNP A/B family of proteins is canonically central to cellular RNA metabolism, but due to their highly conserved nature, the functional differences between hnRNP A1, A2/B1, A0, and A3 are often overlooked. In this review, we explore and identify the shared and disparate homeostatic and disease-related functions of the hnRNP A/B family proteins, highlighting areas where the proteins have not been clearly differentiated. Herein, we provide a comprehensive assembly of the literature on these proteins. We find that there are critical gaps in our grasp of A/B proteins' alternative splice isoforms, structures, regulation, and tissue and cell-type-specific functions, and propose that future mechanistic research integrating multiple A/B proteins will significantly improve our understanding of how this essential protein family contributes to cell homeostasis and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据