期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2021.723996
关键词
mitochondria; fatty acid oxidation; succinylation; sirtuins; lysine acetylation; glucose oxidation
资金
- Canadian Institutes for Health Research
- Alberta Diabetes Institute Graduate Studentship Award
Perturbations in myocardial energy substrate metabolism are key contributors to heart diseases, with post-translational acetylation-mediated modification of metabolic enzymes emerging as an important regulatory mechanism. However, the functional consequences of acetylation changes on metabolic alterations and myocardial dysfunction are not clearly defined.
Perturbations in myocardial energy substrate metabolism are key contributors to the pathogenesis of heart diseases. However, the underlying causes of these metabolic alterations remain poorly understood. Recently, post-translational acetylation-mediated modification of metabolic enzymes has emerged as one of the important regulatory mechanisms for these metabolic changes. Nevertheless, despite the growing reports of a large number of acetylated cardiac mitochondrial proteins involved in energy metabolism, the functional consequences of these acetylation changes and how they correlate to metabolic alterations and myocardial dysfunction are not clearly defined. This review summarizes the evidence for a role of cardiac mitochondrial protein acetylation in altering the function of major metabolic enzymes and myocardial energy metabolism in various cardiovascular disease conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据