Advances in Cardiotoxicity Induced by Altered Mitochondrial Dynamics and Mitophagy

Mitochondria are the most abundant organelles in cardiac cells, and are essential to maintain the normal cardiac function, which requires mitochondrial dynamics and mitophagy to ensure the stability of mitochondrial quantity and quality. When mitochondria are affected by continuous injury factors, the balance between mitochondrial dynamics and mitophagy is broken. Aging and damaged mitochondria cannot be completely removed in cardiac cells, resulting in energy supply disorder and accumulation of toxic substances in cardiac cells, resulting in cardiac damage and cardiotoxicity. This paper summarizes the specific underlying mechanisms by which various adverse factors interfere with mitochondrial dynamics and mitophagy to produce cardiotoxicity and emphasizes the crucial role of oxidative stress in mitophagy. This review aims to provide fresh ideas for the prevention and treatment of cardiotoxicity induced by altered mitochondrial dynamics and mitophagy.

Automated summary

Mitochondria play a crucial role in maintaining normal cardiac function, but continuous damage can disrupt the balance of mitochondrial dynamics and mitophagy, leading to energy supply disorders and toxic accumulation in cardiac cells, ultimately resulting in cardiac damage and toxicity. This review highlights the importance of oxidative stress in mitophagy and aims to provide insights for preventing and treating cardiotoxicity caused by altered mitochondrial dynamics and mitophagy.