期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2021.707701
关键词
non-high-density lipoprotein cholesterol; hypertension; all-cause mortality; cardiovascular mortality; NHANES
资金
- Science and Technology Plan Program of Guangzhou [201803040012]
- Key Area R&D Program of Guangdong Province [2019B020227005]
- Guangdong Provincial People's Hospital Clinical Research Fund [Y012018085]
- Fundamental and Applied Basic Research Foundation Project ofGuangdong Province [2020A1515010738]
- Climbing Plan of Guangdong Provincial People's Hospital [DFJH2020022]
The study found a U-shaped association between non-HDL-C and mortality in hypertensive population, with a significant decrease in all-cause mortality for every 10 mg/dl increase below the threshold of 158 mg/dl, and a significant positive association with cardiovascular mortality above 190 mg/dl. Similar results were seen in subgroups such as participants under 65 years old, non-white population, non-users of lipid-lowering drugs, and those with a BMI >= 25 kg/m(2).
Background: Non-high-density lipoprotein cholesterol (non-HDL-C) is a valuable indicator in routine blood lipid tests, but the associations of non-HDL-C with mortality in hypertensive population still remain uncertain. Methods: In the National Health and Nutrition Examination Surveys from 1999 to 2014, participants having hypertension were included and grouped by non-HDL-C levels (< 130, 130-159, 160-189, 190-219, and >= 220 mg/dl). Multivariate Cox regression was conducted for calculation of hazard ratios (HR) and 95% confidence interval (CI). To reveal the relationship between non-HDL-C and mortality, Kaplan-Meier survival curves, restricted cubic spline, linear regression, and subgroup analysis were also applied. Results: A total of 12,169 participants (47.52% males, mean age 57.27 +/- 15.79 years) were included. During average follow-up of 92.5 months, 1,946 (15.99%) all-cause deaths and 422 (3.47%) cardiovascular deaths occurred. After adjusting for confounders, the association of non-HDL-C with mortality was detected as U-shaped. Threshold values were observed at 158 mg/dl for all-cause mortality and 190 mg/dl as to cardiovascular mortality. Below the threshold, every 10 mg/dl increment in non-HDL-C attributed to relatively low all-cause mortality significantly (HR = 0.94, 95% CI: 0.92-0.96). Above the threshold, non-HDL-C has significant positive associations with both all-cause (HR = 1.03, 95% CI: 1.01-1.05) and cardiovascular mortality (HR = 1.09, 95% CI: 1.05-1.14). For subgroups analysis, similar results were found among participants age < 65 years old, non-white population, those were not taking lipid-lowering drugs, and subjects with body mass index (BMI) >= 25 kg/m(2). Conclusion: The U-shaped association was detected between non-HDL-C and mortality among hypertensive population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据