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The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies

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CELL DEATH DISCOVERY
卷 7, 期 1, 页码 -

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SPRINGERNATURE
DOI: 10.1038/s41420-021-00645-3

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资金

  1. Zhong Yuan Thousand Talents Program-the Zhong Yuan Eminent Doctor in Henan Province [ZYQR201810107]
  2. National Natural Science Foundation of China [U2004117]
  3. Zhong Yuan Elite Project-the Zhong Yuan Leading Talents for Science and Technology Innovation [YXKC2020012]
  4. Henan Postdoctoral Foundation

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Extracellular vesicles (EVs) are small membranous vesicles widely present in human body fluids, containing ncRNAs that play crucial roles in disease progression, especially in cancer development. This review summarizes the biological functions of EV ncRNAs in gynecological malignancies and their potential applications in diagnosis and treatment.
Extracellular vesicles (EVs) are small membranous vesicles secreted by multiple kinds of cells and are widely present in human body fluids. EVs containing various constituents can transfer functional molecules from donor cells to recipient cells, thereby mediating intercellular communication. Noncoding RNAs (ncRNAs) are a type of RNA transcript with limited protein-coding capacity, that have been confirmed to be enriched in EVs in recent years. EV ncRNAs have become a hot topic because of their crucial regulating effect in disease progression, especially in cancer development. In this review, we summarized the biological functions of EV ncRNAs in the occurrence and progression of gynecological malignancies. In addition, we reviewed their potential applications in the diagnosis and treatment of gynecological malignancies.

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