期刊
COMMUNICATIONS BIOLOGY
卷 4, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s42003-021-02148-4
关键词
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资金
- Research Grant Council of the Government of Hong Kong SAR [C5026-16G]
- Research Impact Fund [R5011-18F]
- National Natural Science Foundation of China [81772250, 81601815]
This study revealed that carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains carry phenotypes on a plasmid formed from the fusion of a virulence plasmid with a conjugative plasmid, causing infections with extremely high mortality rates in various countries. The conjugative plasmid identified in a clinical CR-HvKP strain enables rapid expression of carbapenem resistance and hypervirulence phenotypes in other strains upon transfer.
Carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains are emerging. Here Xie et al. show that these phenotypes are carried on a plasmid formed from the fusion of a virulence plasmid with a conjugative plasmid. Carbapenem-resistant and hypervirulent K. pneumoniae (CR-HvKP) strains that have emerged recently have caused infections of extremely high mortality in various countries. In this study, we discovered a conjugative plasmid that encodes carbapenem resistance and hypervirulence in a clinical ST86 K2 CR-HvKP, namely 17ZR-91. The conjugative plasmid (p17ZR-91-Vir-KPC) was formed by fusion of a non-conjugative pLVPK-like plasmid and a conjugative bla(KPC-2)-bearing plasmid and is present dynamically with two other non-fusion plasmids. Conjugation of p17ZR-91-Vir-KPC to other K. pneumoniae enabled them to rapidly express the carbapenem resistance and hypervirulence phenotypes. More importantly, genome analysis provided direct evidence that p17ZR-91-Vir-KPC could be directly transmitted from K2 CR-HvKP strain, 17ZR-91, to ST11 clinical K. pneumoniae strains to convert them into ST11 CR-HvKP strains, which explains the evolutionary mechanisms of recently emerged ST11 CR-HvKP strains.
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