4.7 Review

When dormancy fuels tumour relapse

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Adaptive T-cell immunity controls senescence-prone MyD88-or CARD11-mutant B-cell lymphomas

Maurice Reimann et al.

Summary: The aberrant B-cell receptor/NF-kB signaling is a hallmark feature of B-cell non-Hodgkin lymphomas, especially in diffuse large B-cell lymphoma (DLBCL). Mutations in CD79B, CARD11, NFKBIZ, and MyD88 deregulate NF-kB but their differential impact on lymphoma development remains to be fully understood. Further investigation into primary mouse lymphomas revealed mutant-specific dependencies that were therapeutically exploitable by anti-programmed cell death 1 check-point blockade, providing insights into potential personalized treatment strategies for human DLBCL subsets.
Article Oncology

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

Eugen Dhimolea et al.

Summary: Our study reveals that treatment-persistent tumor cells in cancer patients adopt a reversible transcriptional program similar to embryonic diapause, which allows them to resist chemotherapy-induced cytotoxicity. Inhibiting Myc activity or interfering with the diapause-like adaptation could be potential therapeutic strategies against chemotherapy-persistent tumor cells.

CANCER CELL (2021)

Article Biochemistry & Molecular Biology

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Yunfan Sun et al.

Summary: This study showed that early-relapse hepatocellular carcinoma (HCC) tumors exhibit innate-like CD8(+) T cells with overexpression of KLRB1 (CD161) and a low cytotoxic state, unlike the exhausted state seen in primary HCC. These cells were associated with a worse prognosis. Additionally, potential immune evasion mechanisms were identified in recurrent tumor cells, which dampen dendritic cell antigen presentation and recruit innate-like CD8(+) T cells.
Article Biochemistry & Molecular Biology

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Sumaiyah K. Rehman et al.

Summary: It has been discovered that cancer cells enter a drug-tolerant persister state to evade treatment, showing similarities with diapause in embryonic development. All cancer cells possess the potential to become drug-tolerant persisters, rather than just a small subpopulation.
Editorial Material Gastroenterology & Hepatology

Therapy-induced senescence - an induced synthetic lethality in liver cancer?

Katharina Wolter et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Cell Biology

Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

Francisco Triana-Martinez et al.

Article Biochemistry & Molecular Biology

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Marcus Ruscetti et al.

Review Biochemistry & Molecular Biology

The force awakens: metastatic dormant cancer cells

So-Yeon Park et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor et al.

NATURE (2020)

Article Multidisciplinary Sciences

G3BP1 controls the senescence-associated secretome and its impact on cancer progression

Amr Omer et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, Research & Experimental

NFATC4 promotes quiescence and chemotherapy resistance in ovarian cancer

Alexander J. Cole et al.

JCI INSIGHT (2020)

Article Biochemistry & Molecular Biology

Lysosomal trapping of palbociclib and its functional implications

Susana Llanos et al.

ONCOGENE (2019)

Article Immunology

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Larissa G.P. Langhi Prata et al.

SEMINARS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

URI is required to maintain intestinal architecture during ionizing radiation

Almudena Chaves-Perez et al.

SCIENCE (2019)

Review Oncology

Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance

Maria Laura De Angelis et al.

FRONTIERS IN ONCOLOGY (2019)

Article Multidisciplinary Sciences

Inducing and exploiting vulnerabilities for the treatment of liver cancer

Cun Wang et al.

NATURE (2019)

Article Multidisciplinary Sciences

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy

Sung Pil Hong et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Late recurrence of breast cancer is associated with pro-cancerous immune microenvironment in the primary tumor

Takashi Takeshita et al.

SCIENTIFIC REPORTS (2019)

Review Cell Biology

The dynamic nature of senescence in cancer

Soyoung Lee et al.

NATURE CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Senescence-associated reprogramming promotes cancer stemness

Maja Milanovic et al.

NATURE (2018)

Review Gastroenterology & Hepatology

Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics

Nina Frey et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Medicine, Research & Experimental

A versatile drug delivery system targeting senescent cells

Daniel Munoz-Espin et al.

EMBO MOLECULAR MEDICINE (2018)

Article Immunology

Quiescent Tissue Stem Cells Evade Immune Surveillance

Judith Agudo et al.

IMMUNITY (2018)

Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Peter R. Galle et al.

JOURNAL OF HEPATOLOGY (2018)

Review Cell Biology

Two-Step Senescence-Focused Cancer Therapies

Cynthia J. Sieben et al.

TRENDS IN CELL BIOLOGY (2018)

Article Medicine, Research & Experimental

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

Isabel Puig et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Editorial Material Biochemistry & Molecular Biology

Targeting senescence

Manuel Serrano et al.

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition

Brian Biehs et al.

NATURE (2018)

Article Multidisciplinary Sciences

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy

Adriana Sanchez-Danes et al.

NATURE (2018)

Article Multidisciplinary Sciences

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Marcus Ruscetti et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer et al.

NATURE (2017)

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

Review Cell Biology

Spatial and Temporal Control of Senescence

Yoko Ito et al.

TRENDS IN CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

ATRX is a regulator of therapy induced senescence in human cells

Marta Kovatcheva et al.

NATURE COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

Article Biochemistry & Molecular Biology

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Jianhui Chang et al.

NATURE MEDICINE (2016)

Review Oncology

YAP/TAZ at the Roots of Cancer

Francesca Zanconato et al.

CANCER CELL (2016)

Article Biochemistry & Molecular Biology

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

Srinivas Malladi et al.

Article Biochemistry & Molecular Biology

Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone

Sambad Sharma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Cell Biology

NOTCH1 mediates a switch between two distinct secretomes during senescence

Matthew Hoare et al.

NATURE CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

Aharon Helman et al.

NATURE MEDICINE (2016)

Article Multidisciplinary Sciences

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Bennett G. Childs et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

Lluc Mosteiro et al.

SCIENCE (2016)

Review Oncology

Forging a signature of in vivo senescence

Norman E. Sharpless et al.

NATURE REVIEWS CANCER (2015)

Review Oncology

Epidemiologic and Molecular Prognostic Review of Glioblastoma

Jigisha P. Thakkar et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2014)

Article Biochemistry & Molecular Biology

Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer

A. Zeuner et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Medicine, Research & Experimental

Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells

Lara H. El Touny et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Multidisciplinary Sciences

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Joseph T. Rodgers et al.

NATURE (2014)

Review Multidisciplinary Sciences

The role of senescent cells in ageing

Jan M. van Deursen

NATURE (2014)

Review Oncology

Inside and out: the activities of senescence in cancer

Pedro A. Perez-Mancera et al.

NATURE REVIEWS CANCER (2014)

Review Immunology

Regulation of Ligands for the NKG2D Activating Receptor

David H. Raulet et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Article Biochemistry & Molecular Biology

Programmed Cell Senescence during Mammalian Embryonic Development

Daniel Munoz-Espin et al.

Article Biochemistry & Molecular Biology

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

Mekayla Storer et al.

Article Oncology

Metastasis Dormancy in Estrogen Receptor-Positive Breast Cancer

Xiang H. -F. Zhang et al.

CLINICAL CANCER RESEARCH (2013)

Article Pharmacology & Pharmacy

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

R. M. Naylor et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)

Review Multidisciplinary Sciences

Tumour heterogeneity and cancer cell plasticity

Corbin E. Meacham et al.

NATURE (2013)

Review Cell Biology

Staying alive Metabolic adaptations to quiescence

James R. Valcourt et al.

CELL CYCLE (2012)

Article Multidisciplinary Sciences

A restricted cell population propagates glioblastoma growth after chemotherapy

Jian Chen et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells

C. Canino et al.

ONCOGENE (2012)

Article Immunology

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

Aya Kobayashi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Multidisciplinary Sciences

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Tae-Won Kang et al.

NATURE (2011)

Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

Review Biochemistry & Molecular Biology

Immunity, Inflammation, and Cancer

Sergei I. Grivennikov et al.

Article Cell & Tissue Engineering

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

Mary Mohrin et al.

CELL STEM CELL (2010)

Review Cell Biology

The essence of senescence

Thomas Kuilman et al.

GENES & DEVELOPMENT (2010)

Article Biotechnology & Applied Microbiology

Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML

Yoriko Saito et al.

NATURE BIOTECHNOLOGY (2010)

Review Multidisciplinary Sciences

The DNA-damage response in human biology and disease

Stephen P. Jackson et al.

NATURE (2009)

Article Multidisciplinary Sciences

IFNα activates dormant haematopoietic stem cells in vivo

Marieke A. G. Essers et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Senescence of activated stellate cells limits liver fibrosis

Valery Krizhanovsky et al.

Review Genetics & Heredity

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Keith W. Orford et al.

NATURE REVIEWS GENETICS (2008)

Review Oncology

Models, mechanisms and clinical evidence for cancer dormancy

Julio A. Aguirre-Ghiso

NATURE REVIEWS CANCER (2007)

Review Biochemistry & Molecular Biology

Cellular senescence in cancer and aging

Manuel Collado et al.

Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Review Multidisciplinary Sciences

Nuclear factor-κB in cancer development and progression

Michael Karin

NATURE (2006)

Review Oncology

Paradoxical roles of the immune system during cancer development

KE de Visser et al.

NATURE REVIEWS CANCER (2006)

Article Biochemistry & Molecular Biology

Reversal of human cellular senescence:: roles of the p53 and p16 pathways

CM Beauséjour et al.

EMBO JOURNAL (2003)

Article Oncology

Cell death in irradiated prostate epithelial cells: role of apoptotic and clonogenic cell kill

GP Bromfield et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2003)

Article Biochemistry & Molecular Biology

Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis

SU Wiemann et al.

FASEB JOURNAL (2002)

Article Multidisciplinary Sciences

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

A Krtolica et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)