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Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis
Steven C. Clifford et al.
CELL CYCLE (2006)
Tyrosine residues 654 and 670 in β-catenin are crucial in regulation of Met-β-catenin interactions
Gang Zeng et al.
EXPERIMENTAL CELL RESEARCH (2006)
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
Amar Gajjar et al.
LANCET ONCOLOGY (2006)
RB and cell cycle progression
C. Giacinti et al.
ONCOGENE (2006)
Expression of Dickkopf genes is strongly reduced in malignant melanoma
S. Kuphal et al.
ONCOGENE (2006)
MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of β-catenin
M Jüllig et al.
APOPTOSIS (2006)
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
F Hamaratoglu et al.
NATURE CELL BIOLOGY (2006)
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
X Zeng et al.
NATURE (2005)
Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1
HE Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Transcription-independent pro-apoptotic functions of p53
UM Moll et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination
S Hino et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
TGF-β and epithelial-to-mesenchymal transitions
J Zavadil et al.
ONCOGENE (2005)
Erk associates with and primes GSK-3β for its inactivation resulting in upregulation of β-catenin
QQ Ding et al.
MOLECULAR CELL (2005)
Epidermal growth factor receptor:: A novel target of the Wnt/β-catenin pathway in liver
XP Tan et al.
GASTROENTEROLOGY (2005)
Functional interaction between β-catenin and FOXO in oxidative stress signaling
MAG Essers et al.
SCIENCE (2005)
Differential roles for the coactivators CBP and p300 on TCF/β-catenin-mediated survivin gene expression
H Ma et al.
ONCOGENE (2005)
Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity
P Hayward et al.
DEVELOPMENT (2005)
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy
C Gajate et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
MGMT gene silencing and benefit from temozolomide in glioblastoma
ME Hegi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Interaction between smad7 and β-catenin:: Importance for transforming growth factor β-induced apoptosis
S Edlund et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
JIJ Leu et al.
NATURE CELL BIOLOGY (2004)
Bim is a suppressor of Myc-induced mouse B cell leukemia
A Egle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
C Leung et al.
NATURE (2004)
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
JE Chipuk et al.
SCIENCE (2004)
A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability
Y Ionov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
KH Emami et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The Bcl-2 protein family and its role in the development of neoplastic disease
D Heiser et al.
EXPERIMENTAL GERONTOLOGY (2004)
Downregulation of β-catenin by p53 involves changes in the rate of β-catenin phosphorylation and Axin dynamics
E Levina et al.
ONCOGENE (2004)
Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity
MS Ricci et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL
KH Maclean et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb
M Lauricella et al.
CELL DEATH AND DIFFERENTIATION (2003)
Apototic signaling cascades
PC Ashe et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2003)
Transforming growth factor-β1 (TGF-β)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-β-activated kinase 1 and mitogen-activated protein kinase kinase 3
S Edlund et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
c-MYC: More than just a matter of life and death
S Pelengaris et al.
NATURE REVIEWS CANCER (2002)
Restoration of E-cadherin/β-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis
AM Lowy et al.
SURGERY (2002)
Apoptotic threshold is lowered by p53 transactivation of caspase-6
TK MacLachan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Loss of β-catenin expression is associated with disease progression in malignant melanoma
JE Osborne
BRITISH JOURNAL OF DERMATOLOGY (2002)
Wnt/Wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear β-catenin-TCF complex
T Kramps et al.
CELL (2002)
Negative feedback loop of Wnt signaling through upregulation of conductin/Axin2 in colorectal and liver tumors
B Lustig et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
TNF ligands and receptors - a matter of life and death
DJ MacEwan
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
WH Hoffman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Increased expression of β-catenin predicts better prognosis in nonsmall cell lung carcinomas
F Hommura et al.
CANCER (2002)
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
A Fortin et al.
JOURNAL OF CELL BIOLOGY (2001)
The machinery of programmed cell death
KC Zimmermann et al.
PHARMACOLOGY & THERAPEUTICS (2001)
Down-regulation of β-catenin by activated p53
E Sadot et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Deregulated β-catenin induces a p53-and ARF-dependent growth arrest and cooperates with Ras in transformation
A Damalas et al.
EMBO JOURNAL (2001)
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
TF Burns et al.
ONCOGENE (2001)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)
The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress
SM Mendrysa et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
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