期刊
PHARMACEUTICALS
卷 14, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ph14070701
关键词
fluorine-18; positron emission tomography (PET); silicon fluoride acceptor (SiFA); radiochemistry
Incorporation of silicon fluoride acceptor (SiFA) moieties into various molecules has enhanced the generation of F-18 radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, along with the enhanced in vivo stability of [F-18]SiFA, makes it a suitable strategy for fluorine-18 incorporation. This review emphasizes the clinical applicability of [F-18]SiFA-labeled compounds and discusses significant radiotracers currently in clinical use.
The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of F-18-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [F-18]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [F-18]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.
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