4.6 Article

Neuropeptide S Receptor Stimulation Excites Principal Neurons in Murine Basolateral Amygdala through a Calcium-Dependent Decrease in Membrane Potassium Conductance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear

Julia Constance Bartsch et al.

Summary: This study identifies Y2R within local GABAergic networks in BNST as key elements in facilitating extinction and reducing return of remote fear memories.

MOLECULAR PSYCHIATRY (2021)

Article Neurosciences

Human-Specific Neuropeptide S Receptor Variants Regulate Fear Extinction in the Basal Amygdala of Male and Female Mice Depending on Threat Salience

Xabier Bengoetxea et al.

Summary: The study revealed that variants of the NPSR1 gene exhibit different phenotypic correlates in the fear-related circuits of the amygdala, affecting the extinction ability of conditioned fear in mice. This finding provides a new mechanism for explaining the high anxiety sensitivity in individuals carrying the ancestral NPSR1 I107 variant.

BIOLOGICAL PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Involvement of Neuropeptide Galanin Receptors 2 and 3 in Learning, Memory and Anxiety in Aging Mice

Felix Locker et al.

Summary: The neuropeptide galanin plays a significant role in learning, memory, and anxiety in mice, with potential therapeutic applications. Aging and loss of GAL-R receptors affect cell survival and neurogenesis, while mouse sub-strain differences significantly impact behavioral parameters.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality

Rainer K. Reinscheid et al.

Summary: The study of the NPS peptide system reveals functional attenuation mutations in human genes, potentially for adaptation to environmental conditions. Ancestral alleles of NPSR1 are found in Neandertal and Denisovan genomes, while derived alleles are present in ancient anatomically modern human genomes, suggesting they arose in modern Homo sapiens. World genotype frequencies for NPSR1 SNPs show regional homogeneity but also support an out-of-Africa scenario, with potential weak or balancing selection indicated by high-frequency polymorphisms. The presence of a hypomorphic mutation in NPS precursor in Eurasian Neandertal genomes suggests introgression into the human gene pool through interbreeding, particularly in Southern Europe.

PEPTIDES (2021)

Article Biochemistry & Molecular Biology

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine

David Ramirez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Structure and dynamics of GPCR signaling complexes

Daniel Hilger et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Structure and dynamics of GPCR signaling complexes

Daniel Hilger et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Multidisciplinary Sciences

Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate

Mayra Delgado-Ramirez et al.

SCIENTIFIC REPORTS (2018)

Article Neurosciences

Neuropeptide S precursor knockout mice display memory and arousal deficits

Xiaobin Liu et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2017)

Article Neurosciences

Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis

Thomas Grund et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Neurosciences

A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats

Christina A. Sanford et al.

NEURON (2017)

Article Pharmacology & Pharmacy

Regulation of voltage gated calcium channels by GPCRs and post-translational modification

Junting Huang et al.

CURRENT OPINION IN PHARMACOLOGY (2017)

Article Neurosciences

Antagonistic negative and positive neurons of the basolateral amygdala

Joshua Kim et al.

NATURE NEUROSCIENCE (2016)

Review Endocrinology & Metabolism

The role of Neuropeptide Y in fear conditioning and extinction

R. O. Tasan et al.

NEUROPEPTIDES (2016)

Article Anatomy & Morphology

Neuropeptide S- and Neuropeptide S receptor-expressing neuron populations in the human pons

Csaba Adori et al.

FRONTIERS IN NEUROANATOMY (2015)

Article Multidisciplinary Sciences

GAL3 receptor KO mice exhibit an anxiety-like phenotype

Susanne M. Brunner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Neurosciences

Molecular Fingerprint of Neuropeptide S-Producing Neurons in the Mouse Brain

Xiaobin Liu et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

Neuropeptide S receptor gene-converging evidence for a role in panic disorder

K. Domschke et al.

MOLECULAR PSYCHIATRY (2011)

Article Multidisciplinary Sciences

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

Kerry J. Ressler et al.

NATURE (2011)

Article Substance Abuse

Neuropeptide S Receptor Gene Expression in Alcohol Withdrawal and Protracted Abstinence in Postdependent Rats

Barbara Ruggeri et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2010)

Article Neurosciences

Neuropeptide S: A transmitter system in the brain regulating fear and anxiety

Hans-Christian Pape et al.

NEUROPHARMACOLOGY (2010)

Article Neurosciences

Intra-amygdala injections of neuropeptide S block fear-potentiated startle

Markus Fendt et al.

NEUROSCIENCE LETTERS (2010)

Article Biochemistry & Molecular Biology

Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and function

Stewart D. Clark et al.

PEPTIDES (2010)

Article Multidisciplinary Sciences

Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system

Marsida Kallupi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Pharmacology & Pharmacy

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

K. Togashi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Biochemistry & Molecular Biology

Structure-activity studies on neuropeptide S -: Identification of the amino acid residues crucial for receptor activation

Adelheid L. Roth et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Inhibition of a background potassium channel by Gq protein α-subunits

XD Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Pharmacology & Pharmacy

Pharmacological characterization of human and murine neuropeptide S receptor variants

RK Reinscheid et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Biochemistry & Molecular Biology

KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents

BC Schroeder et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)