期刊
PHARMACEUTICALS
卷 14, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ph14090842
关键词
topical formulation; anti-cellulite; cosmetic; monoterpenoids; accelerated stability
资金
- Royal Golden Jubilee Program (RGJ-PhD) [0008/2560]
- Thailand Center of Excellence for Life Sciences (TCEL) [TC-A2/62]
- National Research Council of Thailand (NRCT) [DBG6080005, IRN61W0005]
- Center of Excellence for Innovation in Chemistry (PERCH-CIC), Ministry of Higher Education, Science, Research and Innovation
The study successfully developed an anti-cellulite emgel with herbal ingredients, and evaluated its stability over a 31-month period. The formulated dosage form showed consistent caffeine content and stable monoterpenes for up to 2 months at 50 degrees Celsius.
Recently, the herbal compress was successfully developed and applied for cellulite treatment. The aim of this study was to formulate a more convenient dosage form of herbal application from the original formula. In addition, we aimed to characterize and evaluate the stability of the developed dosage form. A gelled emulsion, or an emgel, incorporated with 0.1 wt% tea and coffee extracts (1:1 ratio) plus 5 wt% essential oils (mixed oil) was prepared. The caffeine content in the finished product obtained from tea and coffee extracts analyzed by HPLC was 48.1 +/- 2.3 mu g/g. The bio-active marker monoterpenes of mixed oil characterized by headspace GCMS were camphene 50.8 +/- 1.8 mu g/mg, camphor 251.0 +/- 3.2 mu g/mg, 3-carene 46.7 +/- 1.8 mu g/mg, alpha-citral 75.0 +/- 2.1 mu g/mg, beta-citral 65.6 +/- 1.3 mu g/mg, limonene 36.8 +/- 6.7 mu g/mg, myrcene 53.3 +/- 4.5 mu g/mg, alpha-pinene 85.2 +/- 0.6 mu g/mg, beta-pinene 88.4 +/- 1.1 mu g/mg, and terpinene-4-ol 104.3 +/- 2.6 mu g/mg. The stability study was carried out over a period of 3 months at 4, 25, and 50 degrees C. The caffeine content showed no significant changes and passed the acceptance criteria of >= 80% at all tested temperatures. However, monoterpenes showed their stability for only 2 months at 50 degrees C. Therefore, the shelf-life of the emgel was, consequently, calculated to be 31 months using the Q10 method. Thus, the anti-cellulite emgel was successfully formulated. The characterization methods and stability evaluation for caffeine and monoterpenes in an emgel matrix were also successfully developed and validated.
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