期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/jpm11080700
关键词
cohort study; hypertension; metabolic syndrome; pre-metabolic syndrome; type 2 diabetes mellitus
资金
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry(IPET) through High Value-added Food Technology Development Program - Ministry of Agriculture, Food and Rural Affairs(MAFRA) [321030-5]
This study aimed to investigate the prevalence of pre-MetSyn and its components, as well as their associations with new-onset T2D or hypertension in Korean men and women aged 40-69 years. The results showed that the prevalence of pre-MetSyn and its components varied by sex and disease, suggesting that specific phenotypes of pre-MetSyn may play a crucial role in predicting and preventing the development of T2D and hypertension.
The aim of this study was to investigate the prevalence of premetabolic syndrome (pre-MetSyn) and its components and to longitudinally examine their association with new-onset type 2 diabetes (T2D) or hypertension. A total of 4037 men and 4400 women aged 40 to 69 years were selected from the Korean Genome and Epidemiology Study, observed from 2001 to 2014. Pre-MetSyn was defined as the presence of one or two components of MetSyn (B, elevated blood pressure; G, elevated glucose; H, low HDL-cholesterol; T, elevated triglycerides; W, increased waist circumference). The prevalence of pre-MetSyn was higher than that of non-MetSyn and MetSyn in both men and women. In multivariate Cox regression analyses, G, T, G+T, W+G, B+G, B+T, W+T, B+H, and H+T in men and G, T, G+H, B+T, and H+T in women were significantly associated with new-onset T2D. B, W, B+H, B+T, W+H, and W+T in men and B, B+T, B+H, B+W, and W+H in women were significantly associated with new-onset hypertension. The prevalence of pre-MetSyn components and their associations with new-onset T2D or hypertension differed according to sex and disease. Our results suggest that specific phenotypes of pre-MetSyn may be important factors for predicting and preventing the development of T2D and hypertension.
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