期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/jpm11080726
关键词
breast cancer; risk-stratified screening; population survey; genetic discrimination; women's perspectives
资金
- Government of Canada through Genome Canada
- Canadian Institutes of Health Research
- Ministere de l'Economie et de l'Innovation du Quebec through Genome Quebec
- Quebec Breast Cancer Foundation
- CHU de Quebec Foundation
- Ontario Research Fund
- Quebec Research Fund-Health (FRQS)
- Canada Research Chair in Oncogenetics
Canadian women have limited knowledge of the regulatory framework for genetic discrimination, and many have concerns about the use of their health information by employers or insurers. Further education on GD and legal protections is needed to facilitate the implementation and uptake of risk prediction strategies informed by genetic factors.
The success of risk-stratified approaches in improving population-based breast cancer screening programs depends in no small part on women's buy-in. Fear of genetic discrimination (GD) could be a potential barrier to genetic testing uptake as part of risk assessment. Thus, the objective of this study was twofold. First, to evaluate Canadian women's knowledge of the legislative context governing GD. Second, to assess their concerns about the possible use of breast cancer risk levels by insurance companies or employers. We use a cross-sectional survey of 4293 (age: 30-69) women, conducted in four Canadian provinces (Alberta, British Colombia, Ontario and Quebec). Canadian women's knowledge of the regulatory framework for GD is relatively limited, with some gaps and misconceptions noted. About a third (34.7%) of the participants had a lot of concerns about the use of their health information by employers or insurers; another third had some concerns (31.9%), while 20% had no concerns. There is a need to further educate and inform the Canadian public about GD and the legal protections that exist to prevent it. Enhanced knowledge could facilitate the implementation and uptake of risk prediction informed by genetic factors, such as the risk-stratified approach to breast cancer screening that includes risk levels.
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