期刊
ISCIENCE
卷 24, 期 9, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2021.103021
关键词
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资金
- MCIU/AEI/FEDER, UE) of Spain [PGC2018-0955931-B-100]
- European Research Council (ERC) under the European Union [864203, BFU2017-86471-P]
- Howard Hughes International Early Career, Secretaria d'Universitats i Recerca
- UCL Excellence Fellowship [GRC 2017 SGR 880]
- AEI [CEX2018-000792-M]
- European Research Council (ERC) [864203] Funding Source: European Research Council (ERC)
Ancient pathogen genomics is a growing field that reconstructs past epidemics, suggesting that Europeans may have introduced deadly paratyphoid fever to post-contact American populations. Despite proposed plague epidemics, genome-wide data from two Spanish soldiers besieging Barcelona in 1652 did not show evidence of plague infection, but did reveal substantial presence of the Salmonella enterica serovar Paratyphi C lineage, linking to paratyphoid fever in colonial Mexico. This supports the idea that Paratyphi C enteric fever was more common in Europe and the Americas in the past.
Ancient pathogen genomics is an emerging field allowing reconstruction of past epidemics. The demise of post-contact American populationsmay, at least in part, have been caused by paratyphoid fever brought by Europeans. We retrieved genome-wide data from two Spanish soldiers who were besieging the city of Barcelona in 1652, during the Reapers' War. Their ancestry derived from the Basque region and Sardinia, respectively, (at that time, this island belonged to the Spanish kingdom). Despite the proposed plague epidemic, we could not find solid evidence for the presence of the causative plague agent in these individuals. However, we retrieved from one individual a substantial fraction of the Salmonella enterica serovar Paratyphi C lineage linked to paratyphoid fever in colonial period Mexico. Our results support a growing body of evidence that Paratyphi C enteric fever was more prevalent in Europe and the Americas in the past than it is today.
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