期刊
BIOMEDICINES
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines9070844
关键词
antiphospholipid antibody syndrome; thrombosis; anticoagulation; activated partial thromboplastin time; dilute Russell viper venom test
Lupus anticoagulant (LA) is a crucial laboratory parameter for the diagnosis and management of antiphospholipid syndrome (APS). Proper detection of LA is essential for long-term treatment of patients with thrombotic events, requiring adherence to guidelines and participation in quality assessment schemes.
Lupus anticoagulant (LA) is one of the three laboratory parameters (the others being antibodies to either cardiolipin or beta 2-glycoprotein I) which defines the rare but potentially devastating condition known as antiphospholipid syndrome (APS). Testing for LA is a challenging task for the clinical laboratory because specific tests for its detection are not available. However, proper LA detection is paramount for patients' management, as its persistent positivity in the presence of (previous or current) thrombotic events, candidate for long term anticoagulation. Guidelines for LA detection have been established and updated over the last two decades. Implementation of these guidelines across laboratories and participation to external quality assessment schemes are required to help standardize the diagnostic procedures and help clinicians for appropriate management of APS. This article aims to review the current state of the art and the challenges that clinical laboratories incur in the detection of LA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据