4.7 Article

Modelling Nonalcoholic Steatohepatitis In Vivo-A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

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The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs

D. H. Ipsen et al.

Summary: This study revealed that different strains and breeders have a significant impact on the development and severity of non-alcoholic steatohepatitis (NASH). Guinea pigs from Charles River exhibited more severe NASH compared to those from Envigo, with differences in liver weight, cholesterol levels, and enzyme markers. These findings underscore the importance of considering the breeder in preclinical research for improved reproducibility and study comparisons.

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