期刊
BIOMEDICINES
卷 9, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines9081074
关键词
bioavailability; pharmacological; mechanisms of action; biological effects; polyphenol; in vitro; in vivo; human; concomitant; drugs
资金
- Instituto de Salud Carlos III [CB16/10/00435]
- Spanish Ministry of Innovation and Science [PID2019-110906RB-I00/AEI/10.13039/501100011033]
- Conselleria, de Sanitat de la Generalitat Valenciana [PROMETEO/2019/097]
- EU [825546]
- European Joint Programming Initiative A Healthy Diet for a Healthy Life (JPI HDHL)
- ERA-NET Cofund ERA-HDHL (EU Horizon 2020 Research and Innovation Program) [696295]
- Generalitat Valenciana
- ERDF funds (OP ERDF of Comunitat Valenciana 2014-2020)
Drugs are bioactive compounds discovered from plants and animals that interact with molecules in our body, offering pharmacological properties that can prevent and treat diseases. Ingesting molecules like polyphenols through diet can improve health and act as a concomitant treatment against various pathologies.
Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.
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