4.7 Article

Vagus Nerve Stimulation with Mild Stimulation Intensity Exerts Anti-Inflammatory and Neuroprotective Effects in Parkinson's Disease Model Rats

期刊

BIOMEDICINES
卷 9, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/biomedicines9070789

关键词

anti-inflammation; less invasive therapy; new experimental device; Parkinson's disease; vagus nerve stimulation

资金

  1. Ministry of Health, Labor, and Welfare of Japan [09156274, 24592129]
  2. Grants-in-Aid for Scientific Research [24592129] Funding Source: KAKEN

向作者/读者索取更多资源

This study examined the efficacy of vagus nerve stimulation (VNS) on Parkinson's disease model rats using a wireless controllable electrical stimulator. The results showed that VNS with 0.25-0.5 mA intensity significantly improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. Further research confirmed the practicality and effectiveness of the new experimental device.
Background: The major surgical treatment for Parkinson's disease (PD) is deep brain stimulation (DBS), but a less invasive treatment is desired. Vagus nerve stimulation (VNS) is a relatively safe treatment without cerebral invasiveness. In this study, we developed a wireless controllable electrical stimulator to examine the efficacy of VNS on PD model rats. Methods: Adult female Sprague-Dawley rats underwent placement of a cuff-type electrode and stimulator on the vagus nerve. Following which, 6-hydroxydopamine (6-OHDA) was administered into the left striatum to prepare a PD model. VNS was started immediately after 6-OHDA administration and continued for 14 days. We evaluated the therapeutic effects of VNS with behavioral and immunohistochemical outcome assays under different stimulation intensity (0.1, 0.25, 0.5 and 1 mA). Results: VNS with 0.25-0.5 mA intensity remarkably improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. On the other hand, VNS with 0.1 mA and 1 mA intensity did not display significant therapeutic efficacy. Conclusions: VNS with 0.25-0.5 mA intensity has anti-inflammatory and neuroprotective effects on PD model rats induced by 6-OHDA administration. In addition, we were able to confirm the practicality and effectiveness of the new experimental device.

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