4.7 Review

Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features

Melissa Jasmin et al.

Summary: The netrin-1/DCC ligand/receptor pair plays key roles in CNS development, and although they are expressed in the adult brain, their function in mature neurons is not well understood. Research shows that netrin-1 plays a critical role in the fate of adult dopamine neurons, and targeting netrin-1 signaling may have therapeutic potential in Parkinson's disease. Studies in animal models suggest that overexpression of netrin-1 or administration of recombinant netrin-1 can be neuroprotective and neurorestorative in PD.

EMBO JOURNAL (2021)

Article Clinical Neurology

Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc

Adelie Salin et al.

Summary: This study found that dopamine activity in the VTA is decreased in rats with extended access to cocaine, while there were no changes in dopamine activity in the SNc. These changes in VTA dopamine activity may contribute to the negative emotional state and the incubation of drug seeking during abstinence.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Striatal activity topographically reflects cortical activity

Andrew J. Peters et al.

Summary: The relationship between cortical and striatal activity is precise, topographic, causal, and invariant to behavior. Striatal activity follows a mediolateral gradient related to different behavioral correlates. This consistent and causal mapping of cortical activity in the striatum is not influenced by task engagement.

NATURE (2021)

Article Multidisciplinary Sciences

Corticostriatal control of defense behavior in mice induced by auditory looming cues

Zhong Li et al.

Summary: Innate defense behaviors in animals in response to approaching threats are mainly mediated by auditory cortex, superior colliculus, and striatum, and looming sounds trigger specific sequential defensive reactions.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Early Adolescence Prefrontal Cortex Alterations in Female Rats Lacking Dopamine Transporter

Placido Illiano et al.

Summary: The study focuses on the PFC function in early adolescent female rats with heterozygous and homozygous ablation of DAT, showing changes in neuronal and glial cell homeostasis. Genetic ablation of DAT in the early adolescent PFC leads to a hyperactive phenotype, alterations in glutamatergic neurotransmission, neurodegeneration, and glial activation. This study provides insight into neuroinflammatory pathological processes in DAT-ablated female rats, potentially offering new investigational approaches in human diseases.

BIOMEDICINES (2021)

Article Neurosciences

Dopamine, Updated: Reward Prediction Error and Beyond

Talia N. Lerner et al.

Summary: Researchers have explored the roles of dopamine neurons in learning from various perspectives, with the reward prediction error (RPE) signal being considered crucial. Recent studies have urged a more nuanced RPE theory by incorporating sensory prediction error, distributional encoding, and belief states. Future research on dopamine neuron diversity is expected to add more details to this theory.

CURRENT OPINION IN NEUROBIOLOGY (2021)

Review Behavioral Sciences

Molecular genetics of substance use disorders: An umbrella review

Sandra Lopez-Leon et al.

Summary: This article provides a comprehensive overview of genetic studies on substance use disorders (SUD) through an umbrella review, revealing alcohol and tobacco as the most studied substances and cannabis, opioids, and cocaine as the least studied. Several genes are associated with multiple SUDs, with SLC6A4 showing the highest OR values across all addictions. GWAS confirmed the role of CHRNA5 in nicotine dependence and identified new candidate genes for further functional analyses in other SUDs.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Multidisciplinary Sciences

Striatal dopamine mediates hallucination-like perception in mice

K. Schmack et al.

Summary: Hallucination-like perception in mice was found to be correlated with elevated dopamine levels and could be induced by optogenetic stimulation, providing insights into the neural circuit mechanisms underlying hallucinations. These findings suggest potential for developing circuit-based treatments for psychotic disorders.

SCIENCE (2021)

Review Medicine, Research & Experimental

Understanding the genetics and neurobiological pathways behind addiction (Review)

Alexandra Popescu et al.

Summary: The occurrence of addiction is influenced by various factors such as genetics, environment, intrinsic factors, extrinsic factors, and the nature of addictive substances. The dopamine-mesolimbic motivation-reward-reinforcement cycle is the most consistent physiological theory in addiction, with addictive substances sharing the common property of being dopamine-agonists but each having individual mechanisms and psychoactive potentials.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Neurosciences

Heterogeneity of Striatal Dopamine Function in Schizophrenia: Meta-analysis of Variance

Stefan P. Brugger et al.

BIOLOGICAL PSYCHIATRY (2020)

Review Neurosciences

Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking

Anne L. Collins et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2020)

Article Neurosciences

Temporally restricted dopaminergic control of reward-conditioned movements

Kwang Lee et al.

NATURE NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Local D2-to D1-neuron transmodulation updates goal-directed learning in the striatum

Miriam Matamales et al.

SCIENCE (2020)

Article Clinical Neurology

Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons

Jimena Monzon-Sandoval et al.

ANNALS OF NEUROLOGY (2020)

Article Biochemistry & Molecular Biology

Ventral Tegmental Dopamine Neurons Control the Impulse Vector during Motivated Behavior

Ryan N. Hughes et al.

CURRENT BIOLOGY (2020)

Article Multidisciplinary Sciences

The SLC6A3 gene polymorphism is related to the development of attentional functions but not to ADHD

Katarzyna Kuc et al.

SCIENTIFIC REPORTS (2020)

Review Pharmacology & Pharmacy

Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia

Jean Claude Martel et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Biochemical Research Methods

An expanded palette of dopamine sensors for multiplex imaging in vivo

Tommaso Patriarchi et al.

NATURE METHODS (2020)

Article Biochemical Research Methods

Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Fangmiao Sun et al.

NATURE METHODS (2020)

Review Biochemistry & Molecular Biology

α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis

Surabhi Mehra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2019)

Review Behavioral Sciences

Hallucinations and Strong Priors

Philip R. Corlett et al.

TRENDS IN COGNITIVE SCIENCES (2019)

Article Multidisciplinary Sciences

Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons

Ben Engelhard et al.

NATURE (2019)

Correction Multidisciplinary Sciences

Dissociable dopamine dynamics for learning and motivation (vol 570, pg 65, 2019)

Ali Mohebi et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Precise Coordination of Three-Dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons

Ryan N. Hughes et al.

CURRENT BIOLOGY (2019)

Review Neurosciences

An integrative framework for perceptual disturbances in psychosis

Guillermo Horga et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Sensory representations in the striatum provide a temporal reference for learning and executing motor habits

Ana E. Hidalgo-Balbuena et al.

NATURE COMMUNICATIONS (2019)

Review Clinical Neurology

Dopamine and addiction: what have we learned from 40 years of research

Marcello Solinas et al.

JOURNAL OF NEURAL TRANSMISSION (2019)

Review Neurosciences

Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms

Robert A. McCutcheon et al.

TRENDS IN NEUROSCIENCES (2019)

Article Psychology, Multidisciplinary

Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children's Math Anxiety

Annelise Julio-Costa et al.

FRONTIERS IN PSYCHOLOGY (2019)

Article Medicine, Research & Experimental

Cell Biology and Pathophysiology of α-Synuclein

Jacqueline Burre et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Review Physiology

The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area

Stephanie C. Gantz et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

Article Biochemistry & Molecular Biology

A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine

Clifford M. Cassidy et al.

CURRENT BIOLOGY (2018)

Article Neurosciences

Striatal synapses, circuits, and Parkinson's disease

Shenyu Zhai et al.

CURRENT OPINION IN NEUROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

Cristine Betzer et al.

EMBO REPORTS (2018)

Review Biochemistry & Molecular Biology

Determinants of dopaminergic neuron loss in Parkinson's disease

Dalton James Surmeier

FEBS JOURNAL (2018)

Article Biochemistry & Molecular Biology

Dopamine Transporter/-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson's Disease: An In Situ Proximity Ligation Assay Study

Francesca Longhena et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Neurosciences

Mitochondrial calcium imbalance in Parkinson's disease

Marthe H. R. Ludtmann et al.

NEUROSCIENCE LETTERS (2018)

Article Multidisciplinary Sciences

C-terminal calcium binding of alpha-synuclein modulates synaptic vesicle interaction

Janin Lautenschlager et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Stable representation of sounds in the posterior striatum during flexible auditory decisions

Lan Guo et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning

Hadley C. Bergstrom et al.

CELL REPORTS (2018)

Review Neurosciences

Progression of Cognitive Decline in Parkinson's Disease

Mandy Roheger et al.

JOURNAL OF PARKINSONS DISEASE (2018)

Article Multidisciplinary Sciences

Diametric neural ensemble dynamics in parkinsonian and dyskinetic states

Jones G. Parker et al.

NATURE (2018)

Article Multidisciplinary Sciences

Dopamine neuron activity before action initiation gates and invigorates future movements

Joaquim Alves da Silva et al.

NATURE (2018)

Article Environmental Sciences

Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients

Jolanta Chmielowiec et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Article Multidisciplinary Sciences

Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses

Tara A. LeGates et al.

NATURE (2018)

Article Clinical Neurology

COMT Val 108/158 Met polymorphism and treatment response to aripiprazole in patients with acute schizophrenia

Haruka Kaneko et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2018)

Article Medicine, Research & Experimental

Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson's disease therapy

Cristina Alcacer et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Clinical Neurology

Epidemiology of Parkinson's disease

Ole-Bjorn Tysnes et al.

JOURNAL OF NEURAL TRANSMISSION (2017)

Article Neurosciences

D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells

Rebecca L. Clarkson et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Genetics & Heredity

Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance

Ashley P. L. Marsh et al.

NATURE GENETICS (2017)

Review Neurosciences

Genetic insights into the neurodevelopmental origins of schizophrenia

Rebecca Birnbaum et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Review Neurosciences

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

Marisela Morales et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease

Annalisa Nobili et al.

NATURE COMMUNICATIONS (2017)

Article Medicine, General & Internal

Parkinson disease

Werner Poewe et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Neurosciences

Pathway-Specific Dopamine Abnormalities in Schizophrenia

Jodi J. Weinstein et al.

BIOLOGICAL PSYCHIATRY (2017)

Review Neurosciences

An Integrative Perspective on the Role of Dopamine in Schizophrenia

Tiago V. Maia et al.

BIOLOGICAL PSYCHIATRY (2017)

Review Neurosciences

Reward and Aversion

Hailan Hu

ANNUAL REVIEW OF NEUROSCIENCE, VOL 39 (2016)

Article Multidisciplinary Sciences

Opponent and bidirectional control of movement velocity in the basal ganglia

Eric A. Yttri et al.

NATURE (2016)

Article Multidisciplinary Sciences

Locus coeruleus and dopaminergic consolidation of everyday memory

Tomonori Takeuchi et al.

NATURE (2016)

Article Multidisciplinary Sciences

Rapid signalling in distinct dopaminergic axons during locomotion and reward

M. W. Howe et al.

NATURE (2016)

Article Neurosciences

The mouse cortico-striatal projectome

Houri Hintiryan et al.

NATURE NEUROSCIENCE (2016)

Article Neurosciences

Mechanisms and functions of GABA co-release

Nicolas X. Tritsch et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Review Neurosciences

Dopamine reward prediction-error signalling: a two-component response

Wolfram Schultz

NATURE REVIEWS NEUROSCIENCE (2016)

Article Neurosciences

Pathway-Specific Striatal Substrates for Habitual Behavior

Justin K. O'Hare et al.

NEURON (2016)

Review Behavioral Sciences

Reappraising striatal D1-and D2-neurons in reward and aversion

Carina Soares-Cunha et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

Article Multidisciplinary Sciences

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

Marija Iljina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

Kimberly A. Kempadoo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Clinical Neurology

The influence of the COMT genotype in the underlying functional brain activity of context processing in schizophrenia and in relatives

Pilar Lopez-Garcia et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2016)

Article Biochemistry & Molecular Biology

Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

Kevin T. Beier et al.

Article Biochemistry & Molecular Biology

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

Talia N. Lerner et al.

Article Neurosciences

Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive

Zev B. Rosen et al.

NATURE NEUROSCIENCE (2015)

Article Neurosciences

Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

Gaetan de lavilleon et al.

NATURE NEUROSCIENCE (2015)

Article Clinical Neurology

Cognitive disorders in Parkinson's disease: Confirmation of a spectrum of severity

Kathy Dujardin et al.

PARKINSONISM & RELATED DISORDERS (2015)

Article Multidisciplinary Sciences

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

Rosemary C. Bagot et al.

NATURE COMMUNICATIONS (2015)

Article Genetics & Heredity

Treatment-resistant schizophrenia and DAT and SERT polymorphisms

Petar Bilic et al.

Article Medicine, Research & Experimental

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation

Guoxiang Liu et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Neurosciences

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Colin G. McNamara et al.

NATURE NEUROSCIENCE (2014)

Article Neurosciences

Multisensory Integration in the Mouse Striatum

Ramon Reig et al.

NEURON (2014)

Review Neurosciences

THE PLACE OF DOPAMINE IN THE CORTICO-BASAL GANGLIA CIRCUIT

S. N. Haber

NEUROSCIENCE (2014)

Article Anatomy & Morphology

Calbindin content and differential vulnerability of midbrain efferent doparninergic neurons in macaques

Iria G. Dopeso-Reyes et al.

FRONTIERS IN NEUROANATOMY (2014)

Review Anatomy & Morphology

Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update

Lars Brichta et al.

FRONTIERS IN NEUROANATOMY (2014)

Review Neurosciences

Upstream deregulation of calcium signaling in Parkinson's disease

Pilar Rivero-Rios et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)

Article Multidisciplinary Sciences

Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination

Petr Znamenskiy et al.

NATURE (2013)

Review Neurosciences

Corticostriatal connectivity and its role in disease

Gordon M. G. Shepherd

NATURE REVIEWS NEUROSCIENCE (2013)

Article Geriatrics & Gerontology

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

Stefanie Reyes et al.

NEUROBIOLOGY OF AGING (2013)

Article Neurosciences

Different dorsal striatum circuits mediate action discrimination and action generalization

Monica Hilario et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2012)

Article Neurosciences

GIRK2 Expression in Dopamine Neurons of the Substantia Nigra and Ventral Tegmental Area

Stefanie Reyes et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2012)

Review Neurosciences

Modulation of Striatal Projection Systems by Dopamine

Charles R. Gerfen et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 (2011)

Review Neurosciences

Experimental and Theoretical Approaches to Conscious Processing

Stanislas Dehaene et al.

NEURON (2011)

Review Pharmacology & Pharmacy

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

Jean-Martin Beaulieu et al.

PHARMACOLOGICAL REVIEWS (2011)

Review Anatomy & Morphology

Basal ganglia disorders associated with imbalances in the striatal striosome and matrix compartments

Jill R. Crittenden et al.

FRONTIERS IN NEUROANATOMY (2011)

Article Multidisciplinary Sciences

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Alexxai V. Kravitz et al.

NATURE (2010)

Review Neurosciences

Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease

Peter Redgrave et al.

NATURE REVIEWS NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation

Carolina Birgner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

Mary Kay Lobo et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Jacqueline Burre et al.

SCIENCE (2010)

Review Neurosciences

Corticostriatal Interactions during Learning, Memory Processing, and Decision Making

Cyriel M. A. Pennartz et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Neurosciences

Dynamic Encoding of Action Selection by the Medial Striatum

Eyal Yaacov Kimchi et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

Perceiving electrical stimulation of identified human visual areas

Dona K. Murphey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors

Martin Darvas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Dopamine Controls Persistence of Long-Term Memory Storage

Janine I. Rossato et al.

SCIENCE (2009)

Article Neurosciences

Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior

Ryan K. Bachtell et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2008)

Review Neurosciences

The cognitive functions of the caudate nucleus

Jessica A. Grahn et al.

PROGRESS IN NEUROBIOLOGY (2008)

Article Multidisciplinary Sciences

Dichotomous dopaminergic control of striatal synaptic plasticity

Weixing Shen et al.

SCIENCE (2008)

Article Psychology, Clinical

Hearing a voice in the noise: auditory hallucinations and speech perception

A. Vercammen et al.

PSYCHOLOGICAL MEDICINE (2008)

Review Neurosciences

Dopamine neuron systems in the brain:: an update

Anders Bjorklund et al.

TRENDS IN NEUROSCIENCES (2007)

Article Neurosciences

Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell

Mark S. Todtenkopf et al.

JOURNAL OF NEUROSCIENCE (2006)

Review Neurosciences

The role of the basal ganglia in habit formation

Henry H. Yin et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Review Neurosciences

LTP and LTD: An embarrassment of riches

RC Malenka et al.

NEURON (2004)

Article Multidisciplinary Sciences

Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(-/-) mice

Y Dong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Medicine, General & Internal

Parkinson's disease

A Samii et al.

LANCET (2004)

Review Neurosciences

AMPA receptor trafficking at excitatory synapses

DS Bredt et al.

NEURON (2003)

Review Neurosciences

Regulation of AMPA receptors during synaptic plasticity

I Song et al.

TRENDS IN NEUROSCIENCES (2002)

Article Multidisciplinary Sciences

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

MA Ungless et al.

NATURE (2001)

Article Multidisciplinary Sciences

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease:: Implications for pathogenesis and therapy

KA Conway et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)