Cytoskeleton Response to Ionizing Radiation: A Brief Review on Adhesion and Migration Effects

The cytoskeleton is involved in several biological processes, including adhesion, motility, and intracellular transport. Alterations in the cytoskeletal components (actin filaments, intermediate filaments, and microtubules) are strictly correlated to several diseases, such as cancer. Furthermore, alterations in the cytoskeletal structure can lead to anomalies in cells' properties and increase their invasiveness. This review aims to analyse several studies which have examined the alteration of the cell cytoskeleton induced by ionizing radiations. In particular, the radiation effects on the actin cytoskeleton, cell adhesion, and migration have been considered to gain a deeper knowledge of the biophysical properties of the cell. In fact, the results found in the analysed works can not only aid in developing new diagnostic tools but also improve the current cancer treatments.

Automated summary

The cytoskeleton plays a crucial role in various biological processes such as adhesion, motility, and intracellular transport. Alterations in its components are linked to diseases like cancer, affecting cell properties and invasiveness. Understanding the effects of ionizing radiations on the cytoskeleton can aid in developing diagnostic tools and improving cancer treatments.