期刊
BIOMEDICINES
卷 9, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines9060589
关键词
regenerative medicine; tissue engineering; vascularization; biomaterials; microvascularization; coculture; gradients
资金
- New Harvest
- Slovene Ministry of Science, Education, and Sport (MIZS) [5442-1/2018/59]
- Slovenian Research Agency (ARRS) [P-0036, J3-1762]
- Young Researcher Programme
The review highlights the current state of microvascular tissue engineering, outlining the challenges faced in developing microvasculature and proposing potential strategies for overcoming these obstacles in future research.
Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale-the microvasculature-that are crucial for oxygen and nutrient delivery. In this review, we present the state of the art in the field of microvascular tissue engineering and demonstrate the challenges for future research in various sections of the field. Finally, we illustrate the potential strategies for addressing some of those challenges.
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