4.7 Review

Zinc Signaling in the Mammary Gland: For Better and for Worse

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis

Thirayost Nimmanon et al.

Summary: This research reveals the crucial role of zinc in cell division, showing how zinc influx through a heteromer of ZIP6 and ZIP10 at a specific time of the cell cycle triggers the pathway leading to mitosis. Blocking this pathway may prevent cells from undergoing mitosis, offering new therapeutic opportunities for proliferative diseases like cancer.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Biochemistry & Molecular Biology

Zinc transporters and their functional integration in mammalian cells

Taiho Kambe et al.

Summary: Zinc is a widely present biological metal with implications for cellular signaling and homeostasis, regulated by zinc transporters in cells. Understanding the molecular functions of zinc transporters can help promote enzymatic reactions, tune cellular responsiveness, and maintain cellular homeostasis.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Neurosciences

The Function and Regulation of Zinc in the Brain

Rebecca F. Krall et al.

Summary: Research has found a rich reserve of free zinc in distinct regions of the brain, concentrated at synaptic boutons, hinting at a possible role in synaptic transmission. Zinc plays various roles in neuronal function, influencing neurotransmission and activating neuronal signaling pathways. These roles are tightly regulated by mechanisms such as metal binding proteins and zinc transporters.

NEUROSCIENCE (2021)

Article Cell Biology

ZnR/GPR39 controls cell migration by orchestrating recruitment of KCC3 into protrusions, re-organization of actin and activation of MMP

Moumita Chakraborty et al.

Summary: Activation of ZnR/GPR39 by Zn2+ regulates cell volume through K+/Cl- co-transporter KCC3, promoting cell proliferation and migration. Additionally, upregulation of KCC3 by ZnR/GPR39 enhances the activity of matrix metalloproteases MMP2 and MMP9.

CELL CALCIUM (2021)

Article Biochemistry & Molecular Biology

Are trace element concentrations suitable biomarkers for the diagnosis of cancer?

Kristina Lossow et al.

Summary: Cancer remains a major cause of death worldwide, and early diagnosis is critical for improved survival rates and treatment success. Studies have shown that cancer patients generally have elevated serum copper levels and diminished zinc levels, with inconsistent changes in selenium and iron levels depending on the type of cancer. Further research is needed to investigate whether these element concentrations can predict the survival probability of cancer patients.

REDOX BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Estrogen receptor-α signaling in post-natal mammary development and breast cancers

Mariam Rusidze et al.

Summary: This review discusses the role of ER alpha in mammary gland development and breast cancer progression, highlighting both the classical nuclear genomic and membrane non-genomic actions of ER alpha in regulating mammary development at different stages. It also provides an overview of the characteristics of luminal cell lineage expressing ER alpha and the impact of ER alpha signaling in transgenic mouse models, emphasizing its pivotal role in mammary gland morphogenesis and function as well as its implication in tumorigenesis. Additionally, the review covers the main features of ER alpha-positive luminal breast cancers and their modeling in mice.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Oncology

HER2-positive breast cancer and tyrosine kinase inhibitors: the time is now

Ilana Schlam et al.

Summary: HER2-positive breast cancer accounts for a significant proportion of cases, with several targeted therapies available including TKIs which have shown promising responses in both early and advanced settings. In patients with central nervous system involvement, TKIs have shown efficacy, which is important for those with limited treatment options and poor prognosis in this setting.

NPJ BREAST CANCER (2021)

Article Biochemistry & Molecular Biology

Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours, breast cancer, and adjacent histologically normal tissue

Kaj Sullivan et al.

Summary: The disruption of Zn homeostasis is associated with breast cancer development and progression. Zinc concentrations and isotopic compositions were analyzed in different types of tissues, showing significant differences between benign and malignant tumours as well as healthy tissues. Zinc isotopic compositions have potential as a diagnostic tool for breast tumours, while further investigation into Zn accumulation in tissues is needed.

METALLOMICS (2021)

Review Biochemistry & Molecular Biology

Regulatory Role of Zinc in Immune Cell Signaling

Bonah Kim et al.

Summary: Zinc is an essential micronutrient with crucial roles in biological processes, and dysregulated zinc homeostasis can impair overall immune function and increase susceptibility to infection. Recent focus on zinc as a beneficial element for immune system support has led to investigations of its immunomodulatory roles in immune cells.

MOLECULES AND CELLS (2021)

Review Oncology

Triple negative breast cancer: A thorough review of biomarkers

Jesse Lopes da Silva et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

Review Oncology

Overcoming Endocrine Resistance in Breast Cancer

Ariella B. Hanker et al.

CANCER CELL (2020)

Review Biotechnology & Applied Microbiology

ERα, A Key Target for Cancer Therapy: A Review

Yanfang Liu et al.

ONCOTARGETS AND THERAPY (2020)

Article Biochemistry & Molecular Biology

Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels

Yukina Nishito et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Physiology

ZnT2 is critical for lysosome acidification and biogenesis during mammary gland involution

Olivia C. Rivera et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease

Michal Hershfinkel

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Zinc supplementation plays a crucial role in T helper 9 differentiation in allogeneic immune reactions and non-activated T cells

Martina Maywald et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2018)

Article Multidisciplinary Sciences

Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth

Hila Ventura-Bixenshpaner et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

The zinc sensing receptor, ZnR/GPR39, in health and disease

Laxmi Sunuwar et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2017)

Review Biochemistry & Molecular Biology

Zinc in Cellular Regulation: The Nature and Significance of Zinc Signals

Wolfgang Maret

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Physiology

Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis

Takafumi Hara et al.

JOURNAL OF PHYSIOLOGICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling

T. Nimmanon et al.

METALLOMICS (2017)

Article Biochemistry & Molecular Biology

The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss

Laxmi Sunuwar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Review Nutrition & Dietetics

Biomarkers of Nutrition for Development (BOND)-Zinc Review

Janet C. King et al.

JOURNAL OF NUTRITION (2016)

Article Physiology

ZnT4 (SLC30A4)-null (lethal milk) mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation

Nicholas H. McCormick et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

Zinc and infant nutrition

M. Leigh Ackland et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)

Article Biochemistry & Molecular Biology

Molecular regulation of lactation: The complex and requisite roles for zinc

Sooyeon Lee et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)

Review Biochemistry & Molecular Biology

A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer

Leslie C. Costello et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)

Article Biochemistry & Molecular Biology

Zinc and immunity: An essential interrelation

Maria Maares et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)

Article Biochemistry & Molecular Biology

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

Kathryn M. Taylor et al.

BIOCHEMICAL JOURNAL (2016)

Review Chemistry, Inorganic & Nuclear

The metal face of protein tyrosine phosphatase 1B

Elisa Bellomo et al.

COORDINATION CHEMISTRY REVIEWS (2016)

Review Food Science & Technology

A Review of Dietary Zinc Recommendations

Rosalind S. Gibson et al.

FOOD AND NUTRITION BULLETIN (2016)

Article Multidisciplinary Sciences

Imaging trace element distributions in single organelles and subcellular features

Yoav Kashiv et al.

SCIENTIFIC REPORTS (2016)

Article Gastroenterology & Hepatology

ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary or Coordinated Secretion and Paneth Cell Function in Mice

Abigail B. Podany et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2016)

Article Biochemistry & Molecular Biology

Decreased Zn2+ Influx Underlies the Protective Role of Hypoxia in Rat Nucleus Pulposus Cells

Yin Xiao-Fan et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2015)

Editorial Material Medicine, Research & Experimental

Zinc isotopes: a novel approach to biomarkers of breast cancer?

Fiona Larner et al.

BIOMARKERS IN MEDICINE (2015)

Article Oncology

The changing role of ER in endocrine resistance

Agostina Nardone et al.

BREAST (2015)

Article Biochemistry & Molecular Biology

Essential Role for Zinc Transporter 2 (ZnT2)-mediated Zinc Transport in Mammary Gland Development and Function during Lactation

Sooyeon Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Cell Biology

TNFα Post-Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes

Stephen R. Hennigar et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

Regulation of neuronal pH by the metabotropic Zn2+ -sensing Gq-coupled receptor, mZnR/GPR39

Thibault Ganay et al.

JOURNAL OF NEUROCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Zinc isotopic compositions of breast cancer tissue

Fiona Larner et al.

METALLOMICS (2015)

Article Neurosciences

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

David Gilad et al.

NEUROBIOLOGY OF DISEASE (2015)

Article Multidisciplinary Sciences

ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution

Stephen R. Hennigar et al.

SCIENTIFIC REPORTS (2015)

Article Cell Biology

The ZnR/GPR39 Interacts With the CaSR to Enhance Signaling in Prostate and Salivary Epithelia

Hila Asraf et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2014)

Review Oncology

The Biology of Zinc Transport in Mammary Epithelial Cells: Implications for Mammary Gland Development, Lactation, and Involution

Nicholas H. McCormick et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2014)

Article Biochemistry & Molecular Biology

Proton-dependent zinc release from intracellular ligands

Lech Kiedrowski

JOURNAL OF NEUROCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Dietary phytate, zinc and hidden zinc deficiency

Harold H. Sandstead et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2014)

Article Multidisciplinary Sciences

High Glucose Level Promotes Migration Behavior of Breast Cancer Cells through Zinc and Its Transporters

Tomoka Takatani-Nakase et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis

Jaromir Gumulec et al.

PLOS ONE (2014)

Article Pediatrics

Zinc deficiency in infants and children: a review of its complex and synergistic interactions

Nancy F. Krebs et al.

PAEDIATRICS AND INTERNATIONAL CHILD HEALTH (2014)

Article Allergy

Regulation of IgE-Dependent Zinc Release from Human Mast Cells

Kazuko Nakashima-Kaneda et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents

Meghan C. McCord et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

Zinc networks: the cell-specific compartmentalization of zinc for specialized functions

Stephen R. Hennigar et al.

BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Discovery of human zinc deficiency: 50 years later

Ananda S. Prasad

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7

Kathryn M. Taylor et al.

SCIENCE SIGNALING (2012)

Review Biochemistry & Molecular Biology

GPR39: a Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions

Petra Popovics et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Review Biochemistry & Molecular Biology

Zinc homeostasis and signaling in health and diseases

Toshiyuki Fukada et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2011)

Article Oncology

Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis

Kimberly S. Peairs et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

Article Biotechnology & Applied Microbiology

The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line

Razinah Sharif et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2011)

Review Nutrition & Dietetics

Zinc in Specialized Secretory Tissues: Roles in the Pancreas, Prostate, and Mammary Gland

Shannon L. Kelleher et al.

ADVANCES IN NUTRITION (2011)

Article Biochemistry & Molecular Biology

Zinc Released from Injured Cells Is Acting via the Zn2+-sensing Receptor, ZnR, to Trigger Signaling Leading to Epithelial Repair

Haleli Sharir et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells

Liang Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Cell Biology

Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells

Linxi Qian et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)

Article Physiology

Zip3 (Slc39a3)functions in zinc reuptake from the alveolar lumen in lactating mammary gland

Shannon L. Kelleher et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2009)

Review Genetics & Heredity

Mammary gland zinc metabolism: regulation and dysregulation

Shannon L. Kelleher et al.

GENES AND NUTRITION (2009)

Article Biochemistry & Molecular Biology

Demonstration and Characterization of the Heterodimerization of ZnT5 and ZnT6 in the Early Secretory Pathway

Ayako Fukunaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Oncology

Zinc Intake From Supplements and Diet and Prostate Cancer

Alejandro Gonzalez et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)

Article Engineering, Biomedical

Zinc presence in invasive ductal carcinoma of the breast and its correlation with oestrogen receptor status

M. J. Farquharson et al.

PHYSICS IN MEDICINE AND BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation

C. Hogstrand et al.

TRENDS IN MOLECULAR MEDICINE (2009)

Review Oncology

Intracellular zinc homeostasis and zinc signaling

Masaaki Murakami et al.

CANCER SCIENCE (2008)

Article Geriatrics & Gerontology

Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc

Wolfgang Maret

EXPERIMENTAL GERONTOLOGY (2008)

Article Biochemistry & Molecular Biology

Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39

Laura Storjohann et al.

FEBS LETTERS (2008)

Review Nutrition & Dietetics

Nutritionally regulated biomarkers for breast cancer

Cathy W. Levenson et al.

NUTRITION REVIEWS (2008)

Article Biochemistry & Molecular Biology

LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway

Le Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Oncology

Triple-negative breast cancer: Clinical features and patterns of recurrence

Rebecca Dent et al.

CLINICAL CANCER RESEARCH (2007)

Article Biochemistry & Molecular Biology

The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer

Kathryn M. Taylor et al.

MOLECULAR MEDICINE (2007)

Article Biochemistry & Molecular Biology

Cellular zinc and redox buffering capacity of metallthionein/thionein in health and disease

Wolfgang Maret et al.

MOLECULAR MEDICINE (2007)

Article Cell Biology

Zinc is a novel intracellular second messenger

Satoru Yamasaki et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum

Shin-Ichiro Yasuda et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2007)

Article Biochemistry & Molecular Biology

Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency

Winyoo Chowanadisai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Public, Environmental & Occupational Health

Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality

N Leone et al.

EPIDEMIOLOGY (2006)

Article Physiology

Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells

YM Kim et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Inhibitory mechanism of store-operated Ca2+ channels by zinc

A Gore et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemical Research Methods

A molecular technique for detecting the liberation of intracellular zinc in cultured neurons

H Hara et al.

JOURNAL OF NEUROSCIENCE METHODS (2004)

Article Biochemistry & Molecular Biology

Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor

H Azriel-Tamir et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival

KL Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters

KM Taylor et al.

BIOCHEMICAL JOURNAL (2004)

Review Cell Biology

Na+/H+ exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes

M Baumgartner et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Zinc fingers can act as Zn2+ sensors to regulate transcriptional activation domain function

AJ Bird et al.

EMBO JOURNAL (2003)

Article Cell Biology

A new mitochondrial fluorescent zinc sensor

SL Sensi et al.

CELL CALCIUM (2003)

Article Pharmacology & Pharmacy

Mechanisms of Zn2+-induced signal initiation through the epidermal growth factor receptor

JM Samet et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)

Article Oncology

Zinc supplement use and risk of prostate cancer

MF Leitzmann et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2003)

Review Biochemistry & Molecular Biology

The LZT proteins; the LIV-1 subfamily of zinc transporters

KM Taylor et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2003)

Article Multidisciplinary Sciences

Prospective identification of tumorigenic breast cancer cells

M Al-Hajj et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Chemistry, Multidisciplinary

Detection and imaging of zinc secretion from pancreatic β-cells using a new fluorescent zinc indicator

KR Gee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)

Article Multidisciplinary Sciences

A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport

M Hershfinkel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

T Sorlie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Nutrition & Dietetics

Zinc and cognitive development

S Bhatnagar et al.

BRITISH JOURNAL OF NUTRITION (2001)

Article Nutrition & Dietetics

The role of zinc in growth and cell proliferation

RS MacDonald

JOURNAL OF NUTRITION (2000)