4.7 Review

Merkel Cell Carcinoma

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Article Dermatology

High somatostatin receptor expression and efficacy of somatostatin analogues in patients with metastatic Merkel cell carcinoma

T. Akaike et al.

Summary: In patients with Merkel cell carcinoma (MCC), most tumors express somatostatin receptors (SSTRs) and treatment with somatostatin analogues (SSAs) can lead to clinically meaningful disease control with minimal side effects. Furthermore, the degree of SSTR expression did not significantly correlate with treatment efficacy, suggesting potential for further exploration of targeting SSTRs in MCC.

BRITISH JOURNAL OF DERMATOLOGY (2021)

Article Dermatology

Metabolic reprogramming and angiogenesis in primary cutaneous Merkel cell carcinoma: expression of hypoxia-inducible factor-1a and its central downstream factors

F. Toberer et al.

Summary: The study highlights the crucial role of HIF-1α in MCC pathogenesis and suggests significant metabolic differences between McPyV(+) and McPyV(-) tumors.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

Letter Dermatology

Divergent differentiation of Merkel cell carcinoma between primary and metastatic lesions

M. Barroil et al.

ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE (2021)

Review Medicine, Research & Experimental

Molecular Pathogenesis of Merkel Cell Carcinoma

James A. DeCaprio

Summary: Merkel cell carcinoma (MCC) has two distinct etiologies, with one caused by viral DNA integration and the other by UV damage. Despite different causes, both forms of MCC have similar presentation, prognosis, and response to therapy. Oncogenic transcriptional programs, cell proliferation rates, and neuroendocrine differentiation programs play important roles in both types of MCC.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

Article Oncology

Activity of ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma

Valerie Glutsch et al.

Summary: In a small retrospective study conducted at three different academic sites in Germany, it was observed that patients with avelumab-refractory metastatic MCC had a high response rate and durable responses to subsequent combined immunotherapy with IPI/NIVO. The data suggests promising activity of second- or third-line PD-1 plus CTLA-4 blockade in patients with anti-PD-L1-refractory MCC.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Review Dermatology

Merkel cell carcinoma

P. Patel et al.

Summary: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that primarily affects older individuals. Diagnosis is typically made through clinical examination and tissue biopsy with immunohistochemistry playing a crucial role. Treatment involves surgical excision for localized disease, while metastatic disease has a poor prognosis but shows promise with immune checkpoint inhibitors.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2021)

Review Dermatology

Merkel cell carcinoma: A review

Noreen M. Walsh et al.

Summary: Merkel cell carcinoma has been the subject of active scientific investigation in recent years, leading to new insights. Despite its rarity, this primary cutaneous neuroendocrine carcinoma, typically affecting the head/neck of elderly individuals, is associated with poor outcomes. Research has identified two pathogenic subsets of the tumor, with the majority linked to a virus and a minority caused by UV radiation-induced genetic damage. Investigation has also shown that the tumor responds to immune checkpoint inhibition, marking a significant advancement in treatment.

JOURNAL OF CUTANEOUS PATHOLOGY (2021)

Article Oncology

Virus-positive Merkel Cell Carcinoma Is an Independent Prognostic Group with Distinct Predictive Biomarkers

Kelly L. Harms et al.

Summary: The study classified Merkel cell carcinoma (MCC) tumors into virus-positive (VP) and virus-negative (VN) types, each displaying distinct sets of prognostic molecular biomarkers. MCPyV status was found to be an independent prognostic factor for MCC, with tumor genome, transcriptome, and microenvironment features modifying prognosis in a manner specific to viral status.

CLINICAL CANCER RESEARCH (2021)

Review Oncology

Immunotherapy for Merkel cell carcinoma

Christina V. Angeles et al.

Summary: Merkel cell carcinoma (MCC) is an aggressive form of skin cancer that, while responsive to chemotherapy, often relapses and develops resistance, limiting the effectiveness of treatment. The management of advanced MCC has been significantly impacted by the introduction of checkpoint inhibitors. Ongoing research is focusing on immunotherapy for MCC in unresectable and metastatic cases, as well as exploring future immune-based strategies for this challenging cancer.

JOURNAL OF SURGICAL ONCOLOGY (2021)

Article Oncology

Mutational Landscape of Virus- and UV-Associated Merkel Cell Carcinoma Cell Lines Is Comparable to Tumor Tissue

Kai Horny et al.

Summary: Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer caused by a virus or chronic UV exposure. The genomic characteristics of MCC cell lines vary based on the presence of the virus, with virus-negative cell lines showing high mutational burden and UV-induced DNA damage, while virus-positive cell lines have low mutational burden but characteristic copy number variations. Understanding these genomic features can aid in further experimental studies on the biological relevance of MCC.

CANCERS (2021)

Review Oncology

Merkel Cell Carcinoma: New Trends

Ellen M. Zwijnenburg et al.

Summary: Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin mainly seen in the elderly, with increasing incidence due to aging population, sun exposure, and immunosuppressive medication use. Early detection and prompt treatment are crucial, with management often involving surgery, radiotherapy, and immunotherapy. Management by an experienced multidisciplinary team is essential due to the rarity, aggressiveness, and frail patient population it concerns.

CANCERS (2021)

Review Oncology

Cancer cell metabolic plasticity in migration and metastasis

Jenna A. Mosier et al.

Summary: Metabolic reprogramming is a hallmark of cancer metastasis, where cancer cells adjust their metabolic pathways to meet the energetic demands of the tumor microenvironment. Mechanical and biochemical factors influence both cell migration and glucose metabolism in cancer cells. Understanding the metabolic plasticity of cancer cells can lead to the development of more effective clinical diagnostics and therapeutics.

CLINICAL & EXPERIMENTAL METASTASIS (2021)

Review Oncology

The Landmark Series: Non-melanoma Skin Cancers

Ann Y. Lee et al.

ANNALS OF SURGICAL ONCOLOGY (2020)

Article Dermatology

Merkel cell carcinoma with divergent differentiation

K. Gaitskell et al.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2020)

Article Oncology

Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial

Suzanne L. Topalian et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Oncology

Merkel Cell Polyomavirus and Merkel Cell Carcinoma

Valeria Pietropaolo et al.

CANCERS (2020)

Editorial Material Dermatology

S2k guidelines for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - update 2018

Juergen C. Becker et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2019)

Review Oncology

Adjuvant radiotherapy for Merkel cell carcinoma: A systematic review and meta-analysis

Fausto Petrelli et al.

RADIOTHERAPY AND ONCOLOGY (2019)

Letter Dermatology

VEGF-A Inhibition as a Potential Therapeutic Approach in Merkel Cell Carcinoma

Thibault Kervarrec et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

Article Multidisciplinary Sciences

Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response

Donglim Esther Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Medicine, General & Internal

Dermoscopy of Melanoma and Non-melanoma Skin Cancers

Junji Kato et al.

FRONTIERS IN MEDICINE (2019)

Article Otorhinolaryngology

Poly ADP-ribose polymerase-1 as a potential therapeutic target in Merkel cell carcinoma

Renata Ferrarotto et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2018)

Article Dermatology

Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics

Kelly G. Paulson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

Article Dermatology

Merkel cell carcinomas infiltrated with CD33= myeloid cells and CD8+ T cells are associated with improved outcome

Thibault Kervarrec et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)

Review Oncology

Merkel Cell Carcinoma, Version 1.2018 Clinical Practice Guidelines in Oncology

Christopher K. Bichakjian et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2018)

Article Oncology

Cabozantinib in Patients with Advanced Merkel Cell Carcinoma

Guilherme Rabinowits et al.

ONCOLOGIST (2018)

Article Oncology

Immunotherapy for Merkel cell carcinoma: a turning point in patient care

Isaac S. Chan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Article Oncology

Resection Margins in Merkel Cell Carcinoma: Is a 1-cm Margin Wide Enough?

Matthew C. Perez et al.

ANNALS OF SURGICAL ONCOLOGY (2018)

Article Pathology

Immunohistochemical profiles of different subsets of Merkel cell carcinoma

Sylvia Pasternak et al.

HUMAN PATHOLOGY (2018)

Review Oncology

Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes

Aric . Colunga et al.

CLINICAL CANCER RESEARCH (2018)

Article Oncology

Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs

Dirk Schadendorf et al.

EUROPEAN JOURNAL OF CANCER (2017)

Review Biochemistry & Molecular Biology

Angiogenesis Inhibitors in NSCLC

Anna Manzo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Effects and Side Effects of Using Sorafenib and Sunitinib in the Treatment of Metastatic Renal Cell Carcinoma

Caroline Randrup Hansen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Oncology

Tumor vascularization and clinicopathologic parameters as prognostic factors in merkel cell carcinoma

A. Bob et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2017)

Article Dermatology

PD-1 and PD-L1 in neoplastic cells and the tumor microenvironment of Merkel cell carcinoma

Christina Mitteldorf et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2017)

Letter Dermatology

Merkel cell carcinoma: morphologic aspects on reflectance confocal microscopy

C. Longo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

Letter Dermatology

Ipilimumab has efficacy in metastatic Merkel cell carcinoma: a case series of five patients

J. K. Winkler et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

Article Medicine, General & Internal

Merkel cell carcinoma

Juergen C. Becker et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Oncology

Radiation Therapy is Associated with Improved Outcomes in Merkel Cell Carcinoma

Tobin Strom et al.

ANNALS OF SURGICAL ONCOLOGY (2016)

Review Dermatology

Complete spontaneous regression of Merkel cell carcinoma (1986-2016): a 30 year perspective

Noreen M. Walsh

JOURNAL OF CUTANEOUS PATHOLOGY (2016)

Article Medicine, General & Internal

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma

Paul T. Nghiem et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Meeting Abstract Oncology

UKMCC-01: A phase II study of pazopanib (PAZ) in metastatic Merkel cell carcinoma.

Paul D. Nathan et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Letter Dermatology

Epidemiology of Merkel cell carcinoma in New Zealand: a population-based study

J. P. Robertson et al.

BRITISH JOURNAL OF DERMATOLOGY (2015)

Article Dermatology

Merkel Cell Polyomavirus Small T Antigen Is Oncogenic in Transgenic Mice

Monique E. Verhaegen et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Dermatology

Dermoscopy of uncommon skin tumours

Aimilios Lallas et al.

AUSTRALASIAN JOURNAL OF DERMATOLOGY (2014)

Article Dermatology

Non-Melanoma Skin Cancer Incidence and Impact of Skin Cancer Screening on Incidence

Nora Eisemann et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Review Dermatology

Skin cancer and photoprotection in people of color: A review and recommendations for physicians and the public

Oma N. Agbai et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Article Medicine, Research & Experimental

Epigenetic Regulation of Epidermal Differentiation

Carolina N. Perdigoto et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)

Article Oncology

Downregulation of MHC-I Expression Is Prevalent but Reversible in Merkel Cell Carcinoma

Kelly G. Paulson et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Article Dermatology

Clinical and dermoscopic characteristics of Merkel cell carcinoma

C. Jalilian et al.

BRITISH JOURNAL OF DERMATOLOGY (2013)

Article Biochemistry & Molecular Biology

Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

Evan S. Bardot et al.

EMBO JOURNAL (2013)

Article Oncology

Rare neuroendocrine tumours: Results of the surveillance of rare cancers in Europe project

Jan Maarten van der Zwan et al.

EUROPEAN JOURNAL OF CANCER (2013)

Article Dermatology

Dermoscopy of Merkel Cell Carcinoma

Stephane Dalle et al.

DERMATOLOGY (2012)

Article Dermatology

The clinical profile of Merkel cell carcinoma in mainland China

Philip I. Song et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2012)

Article Hematology

Effects of hypoxia and HIFs on cancer metabolism

Vera Mucaj et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2012)

Article Dermatology

Dermatoscopic vascular patterns in cutaneous Merkel cell carcinoma

Mandy S. Harting et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2012)

Article Dermatology

Merkel cell carcinoma induces lymphatic microvessel formation

Siegfried Werchau et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2012)

Article Dermatology

Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival

J. Girschik et al.

BRITISH JOURNAL OF DERMATOLOGY (2011)

Article Immunology

Age-Specific Seroprevalence of Merkel Cell Polyomavirus, BK Virus, and JC Virus

Raphael P. Viscidi et al.

CLINICAL AND VACCINE IMMUNOLOGY (2011)

Article Orthopedics

Rising incidence of Merkel cell carcinoma

Dorte Lyhne et al.

JOURNAL OF PLASTIC SURGERY AND HAND SURGERY (2011)

Article Oncology

A Phase II Trial of Imatinib Mesylate in Merkel Cell Carcinoma (Neuroendocrine Carcinoma of the Skin) A Southwest Oncology Group Study (S0331)

Wolfram E. Samlowski et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2010)

Article Dermatology

Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study

Jorge Albores-Saavedra et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2010)

Article Oncology

Merkel Cell Carcinoma: Incidence, Mortality, and Risk of Other Cancers

Jeanette Kaae et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

Article Dermatology

Vascular density has prognostic value in Merkel cell carcinoma

Lydia Ng et al.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2008)

Article Dermatology

Merkel cell carcinoma:: molecular pathogenesis, clinical features and therapy

Juergen C. Becker et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2008)

Article Dermatology

Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients:: the AEIOU features

Michelle Heath et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2008)

Article Multidisciplinary Sciences

Clonal integration of a polyomavirus in human Merkel cell carcinoma

Huichen Feng et al.

SCIENCE (2008)

Review Biochemistry & Molecular Biology

Two faces of p53: aging and tumor suppression

Francis Rodier et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Pathology

Expression profiles associated with aggressive behavior in Merkel cell carcinoma

Maria-Teresa Fernandez-Figueras et al.

MODERN PATHOLOGY (2007)

Article Oncology

Does chemotherapy improve survival in high-risk Stage I and II Merkel cell carcinoma of the skin?

MG Poulsen et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)

Article Oncology

Merkel cell carcinoma: Changing incidence trends

NC Hodgson

JOURNAL OF SURGICAL ONCOLOGY (2005)

Article Dermatology

Vascular structures in skin tumors - A dermoscopy study

G Argenziano et al.

ARCHIVES OF DERMATOLOGY (2004)