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The emerging role of RNA N6-methyladenosine methylation in breast cancer

期刊

BIOMARKER RESEARCH
卷 9, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s40364-021-00295-8

关键词

RNA methylation; Breast cancer; Clinicopathological features; Prognosis; Drug target

资金

  1. National Key R&D Program of China [2018YFC0115204]
  2. Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences Clinical and Translational Medicine Research Fund [12019XK320071]
  3. CSCO Pilot Oncology Research Fund [Y-2019AZMS0377]
  4. Capital Health Development Research Project [2018-2-4023]

向作者/读者索取更多资源

The m6A modification plays a crucial role in breast cancer development, with potential for serving as a therapeutic target. Studies on the biological function and prognostic value of m6A modification in breast cancer are ongoing.
N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.

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