期刊
JOURNAL OF INFLAMMATION RESEARCH
卷 14, 期 -, 页码 2723-2730出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S313200
关键词
growth differentiation factor-15; testosterone; suicidal ideation; major depressive disorder
类别
资金
- Fundamental Research Funds for the Central Universities [2042020kf0064]
- Renmin Hospital of Wuhan University
Elevated levels of GDF-15 were found to be significantly associated with an increased risk of suicidal ideation among patients with depression, with this association partly mediated by low testosterone levels.
Background: Elevated levels of growth differentiation factor (GDF)-15 and reduced levels of testosterone have been linked to depressive disorder, but whether they are also linked to suicidal ideation in patients with depression is unclear. Methods: This retrospective study involved 301 patients >= 22 years old hospitalized for depression between July 2018 and November 2020 at Renmin Hospital of Wuhan University, of whom 120 had suicidal ideation. Serum levels of GDF-15 and testosterone were compared between patients with or without suicidal ideation. Results: GDF-15 levels were significantly higher among patients with suicidal ideation than among those without, regardless of whether testosterone levels were above or below the median of 314 ng/dL. In multivariate logistic regression involving all patients, serum GDF-15 level was associated with low testosterone level (P=0.001). Among patients with testosterone <314 ng/dL, an increase of 1 standard deviation in serum GDF-15 level translated to a 1.3-fold increase in the risk of suicidal ideation (P=0.007). This relationship was not observed in all population or patients with testosterone levels >= 314 ng/dL. Conclusion: High serum GDF-15 level may be associated with an increased risk of suicidal ideation in patients with depression, and this association appears to be partly mediated by low testosterone levels.
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