Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.

Automated summary

The study demonstrated that a senolytic cocktail (dasatinib+quercetin) could enhance osteogenic capacity of aged BMSCs, providing a potential strategy for improving BMSC function in elderly populations.