相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Cell of Origin Influences Pancreatic Cancer Subtype
Brittany M. Flowers et al.
CANCER DISCOVERY (2021)
Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells
Louis Collet et al.
GUT (2020)
Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma
Alex Y. L. Lee et al.
GUT (2019)
Differential Cell Susceptibilities to Kras(G12D) in the Setting of Obstructive Chronic Pancreatitis
Chanjuan Shi et al.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2019)
β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
Bernhard W. Renz et al.
CANCER CELL (2018)
Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes
Cristina Aguayo-Mazzucato et al.
CELL METABOLISM (2018)
Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis
Spencer G. Willet et al.
EMBO JOURNAL (2018)
Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice
Janel L. Kopp et al.
GASTROENTEROLOGY (2018)
ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice
Yoshito Kimura et al.
GASTROENTEROLOGY (2018)
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
Krushna C. Patra et al.
NATURE CELL BIOLOGY (2018)
In vivo reprogramming drives Kras-induced cancer development
Hirofumi Shibata et al.
NATURE COMMUNICATIONS (2018)
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
Isidoro Cobo et al.
NATURE (2018)
Precancerous neoplastic cells can move through the pancreatic ductal system
Alvin P. Makohon-Moore et al.
NATURE (2018)
Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness
Bernhard W. Renz et al.
CANCER DISCOVERY (2018)
Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4
Waki Hosoda et al.
JOURNAL OF PATHOLOGY (2017)
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
Peter Storz
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)
Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression
Rute M. M. Ferreira et al.
CELL REPORTS (2017)
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
Nouha Ben-Othman et al.
CELL (2017)
GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm
K. Taki et al.
ONCOGENE (2016)
p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells
J. M. Bailey et al.
ONCOGENE (2016)
KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis
Daoyan Wei et al.
CANCER CELL (2016)
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis
C. Benedikt Westphalen et al.
CELL STEM CELL (2016)
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Damian Wollny et al.
DEVELOPMENTAL CELL (2016)
Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A
Chinh Q. Hoang et al.
MOLECULAR AND CELLULAR BIOLOGY (2016)
Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer
Jami L. Saloman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure
Maayan Baron et al.
CELL SYSTEMS (2016)
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas
Olca Basturk et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2015)
Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation
Nilotpal Roy et al.
GENES & DEVELOPMENT (2015)
GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma
Marcus C. Tan et al.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2015)
GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas
Waki Hosoda et al.
VIRCHOWS ARCHIV (2015)
Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition
Ronan Russell et al.
NATURE COMMUNICATIONS (2015)
SOX9 regulates ERBB signalling in pancreatic cancer development
Adrien Grimont et al.
GUT (2015)
Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia
Florencia McAllister et al.
CANCER CELL (2014)
Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
Lola Rahib et al.
CANCER RESEARCH (2014)
DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer
Jennifer M. Bailey et al.
GASTROENTEROLOGY (2014)
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation
Guido von Figura et al.
GUT (2014)
Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers
Simona Chera et al.
NATURE (2014)
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
Guido von Figura et al.
NATURE CELL BIOLOGY (2014)
Pancreatic Adenocarcinoma
NEW ENGLAND JOURNAL OF MEDICINE (2014)
London Pancreas Workshop 2014 Edited by Hemanth Kocher Volume 14, Issue 2, Supplement 1, Pages e1-e6 (March-April 2014) Abstracts
[Anonymous]
PANCREATOLOGY (2014)
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
Fong Cheng Pan et al.
DEVELOPMENT (2013)
Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma
Janel L. Kopp et al.
CANCER CELL (2012)
The Pancreas Cancer Microenvironment
Christine Feig et al.
CLINICAL CANCER RESEARCH (2012)
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
Pierre-Paul Prevot et al.
GUT (2012)
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Meredith A. Collins et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Global Cancer Statistics
Ahmedin Jemal et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2011)
Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
Carmen Guerra et al.
CANCER CELL (2011)
Suppression of Ptf1a Activity Induces Acinar-to-Endocrine Conversion
Daniel Hesselson et al.
CURRENT BIOLOGY (2011)
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
Janel L. Kopp et al.
DEVELOPMENT (2011)
Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice
Angela Criscimanna et al.
GASTROENTEROLOGY (2011)
Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes
Mari Mino-Kenudson et al.
GUT (2011)
Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis
Alyssa L. Kennedy et al.
MOLECULAR CELL (2011)
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
Kenichiro Furuyama et al.
NATURE GENETICS (2011)
Epithelial Tissues Have Varying Degrees of Susceptibility to KrasG12D-Initiated Tumorigenesis in a Mouse Model
Kevin C. Ray et al.
PLOS ONE (2011)
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Jian Wu et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer
Ferdinandos Skoulidis et al.
CANCER CELL (2010)
Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma
Linda Hanlon et al.
CANCER RESEARCH (2010)
LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest
Jennifer P. Morton et al.
GASTROENTEROLOGY (2010)
β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
John P. Morris et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Fabrizio Thorel et al.
NATURE (2010)
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
Meritxell Rovira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice
Claire Bonal et al.
GASTROENTEROLOGY (2009)
Ras Activity Levels Control the Development of Pancreatic Diseases
Baoan Ji et al.
GASTROENTEROLOGY (2009)
DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer
Christine A. Iacobuzio-Donahue et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin
Chanjuan Shi et al.
MOLECULAR CANCER RESEARCH (2009)
β cells can be generated from endogenous progenitors in injured adult mouse pancreas
Xiaobo Xu et al.
CELL (2008)
Hedgehog signaling is required for effective regeneration of exocrine pancreas
Volker Fendrich et al.
GASTROENTEROLOGY (2008)
Notch signaling is required for exocrine regeneration after acute pancreatitis
Jens T. Sivere et al.
GASTROENTEROLOGY (2008)
Reprogramming pancreatic exocrine cells to β-cells
[Anonymous]
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
De La O. Jean-Paul et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
Nils Habbe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Qiao Zhou et al.
NATURE (2008)
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
Patrick C. Hermann et al.
CELL STEM CELL (2007)
Concomitant pancreatic activation of KrasG12D and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
Jens T. Siveke et al.
CANCER CELL (2007)
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
Liqin Zhu et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
Catherine Carriere et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinorna by k-Ras Oncogenes in adult mice
Carmen Guerra et al.
CANCER CELL (2007)
Identification of pancreatic cancer stem cells
Chenwei Li et al.
CANCER RESEARCH (2007)
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression
Hideaki Ijichi et al.
GENES & DEVELOPMENT (2006)
Pancreatic regeneration in chronic pancreatitis requires activation of the Notch signaling pathway
Yun Su et al.
JOURNAL OF GASTROINTESTINAL SURGERY (2006)
Genetics and biology of pancreatic ductal adenocarcinoma
Aram F. Hezel et al.
GENES & DEVELOPMENT (2006)
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
N Bardeesy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mist1-Kras(G12D) knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma
DA Tuveson et al.
CANCER RESEARCH (2006)
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
BZ Stanger et al.
CANCER CELL (2005)
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
AL Means et al.
DEVELOPMENT (2005)
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways
DF Cao et al.
MODERN PATHOLOGY (2005)
Trp53R172H and KraSG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
SR Hingorani et al.
CANCER CELL (2005)
Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
JN Jensen et al.
GASTROENTEROLOGY (2005)
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Y Dor et al.
NATURE (2004)
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
AJ Aguirre et al.
GENES & DEVELOPMENT (2003)
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani et al.
CANCER CELL (2003)
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Y Miyamoto et al.
CANCER CELL (2003)
Pancreatic intraepithelial neoplasia -: A new nomenclature and classification system for pancreatic duct lesions
RH Hruban et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2001)
A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
M Wagner et al.
GENES & DEVELOPMENT (2001)
分享论文
