期刊
BIOACTIVE MATERIALS
卷 9, 期 -, 页码 316-331出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.08.002
关键词
Artificial extracellular matrices; Mechanical reciprocity; Collagen; Fibrin; Polyisocyanides
资金
- European Union [642687]
- National Natural Science Foundation of China [81703584, 51803046]
- Youth Innovation Promotion Association of CAS [2019350]
- Guangdong Natural Science Foundation [2019A1515011277]
- Shenzhen Fundamental Research Foundation [JCYJ20180507182237428]
- Marie Curie Actions (MSCA) [642687] Funding Source: Marie Curie Actions (MSCA)
This article emphasizes the importance of three-dimensional hydrogel models in understanding and predicting cell behavior, highlighting the reciprocal interactions between cells and the extracellular matrix in regulating tissue functions. The structure, uses, advantages, and limitations of commonly used biopolymer networks, such as collagen, fibrin gels, and polyisocyanide gel, are discussed to provide guidance for tissue engineers and biophysicists in designing and utilizing these materials for 3D cell culture purposes.
Three-dimensional (3D) matrix models using hydrogels are powerful tools to understand and predict cell behavior. The interactions between the cell and its matrix, however is highly complex: the matrix has a profound effect on basic cell functions but simultaneously, cells are able to actively manipulate the matrix properties. This (mechano)reciprocity between cells and the extracellular matrix (ECM) is central in regulating tissue functions and it is fundamentally important to broadly consider the biomechanical properties of the in vivo ECM when designing in vitro matrix models. This manuscript discusses two commonly used biopolymer networks, i.e. collagen and fibrin gels, and one synthetic polymer network, polyisocyanide gel (PIC), which all possess the characteristic nonlinear mechanics in the biological stress regime. We start from the structure of the materials, then address the uses, advantages, and limitations of each material, to provide a guideline for tissue engineers and biophysicists in utilizing current materials and also designing new materials for 3D cell culture purposes.
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