期刊
BIOACTIVE MATERIALS
卷 6, 期 7, 页码 2070-2088出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.12.026
关键词
Tissue engineering; Wound healing; Skin; Magnetic nanoparticles; Nanofiber
资金
- Cairo University
In this study, magnetite nanoparticles doped with antimicrobial silver ions were incorporated into electrospun nanofibrous epsilon-polycaprolactone scaffolds. The results demonstrated that increasing silver content in the scaffolds enhanced cell adhesion and growth, as well as antibacterial activity against E. coli and S. aureus. The wound healing rate in rats also increased proportionally with the concentration of silver in the scaffolds, indicating the potential of these composite nanofibrous scaffolds for wound dressings and reconstructive skin therapies.
Skin wounds can lead to numerous complications with dangerous health consequences. In this work, magnetite nanoparticles were doped with different concentrations of antimicrobial silver (Ag) ions and incorporated into the electrospun nanofibrous epsilon-polycaprolactone (PCL) scaffolds. Nanoparticles and scaffolds with various Ag contents were characterized using a range of physicochemical techniques. Ag entered magnetite as cations and preferentially positioned at tetrahedral sites, introducing lattice distortions and topographic irregularities. Amorphization of the structure due to accommodation of Ag expanded the lattice in the bulk and contracted it on the surface, where broadened distribution of Fe-O coordinations was detected. Promoting spin canting and diminishing the double exchange interaction through altered distribution of ferric and ferrous ions, Ag softened the magnetism of magnetite. By making the nanoparticle structure more defective, Ag modified the interface with the polymer and promoted the protrusion of the nanoparticles from the surface of the polymeric nanofibers, thus increasing their roughness and hydrophilicity, with positive repercussions on cell adhesion and growth. Both the viability of human melanocytes and the antibacterial activity against E. coli and S. aureus increased with the concentration of Ag in the magnetite phase of the scaffolds. Skin wound healing rate in rats also increased in direct proportion with the concentration of Ag in the magnetite phase, and no abnormalities in the dermal and epidermal tissues were visible on day 10 in the treatment group. These results imply an excellent potential of these composite nanofibrous scaffolds for use as wound dressings and in other reconstructive skin therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据