期刊
BIOACTIVE MATERIALS
卷 6, 期 6, 页码 1618-1627出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.11.011
关键词
Nitric oxide; Bio-clickable peptide mimic; Synergic modification; Anti-thrombosis; Anti-infection
资金
- National Natural Science Foundation of China [82072072]
- National Key Research and Development Program of China [2017YFB0702504]
- International Cooperation Project by Science and Technology Department of Sichuan Province [2019YFH0103]
- Fundamental Research Funds for the Central Universities [2682020ZT76]
- Innovation and Technology Fund from the Innovation and Technology Commission of Hong Kong [ITS/065/19]
The surface modification of extracorporeal circuits and indwelling medical devices using nitric oxide and antibacterial peptide can prevent thrombosis and infection, reducing clinical complications.
Application of extracorporeal circuits and indwelling medical devices has saved many lives. However, it is accompanied with two major complications: thrombosis and infection. To address this issue, we apply therapeutic nitric oxide gas (NO) and antibacterial peptide for synergistically tailoring such devices for surface antithrombogenic and antifouling dual functions. Such functional surface is realized by stepwise conjugation of NO-generating compound of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelated copper ions (Cu-DOTA) and dibenzylcyclooctyne- (DBCO-) modified antimicrobial peptide based on carbodiimide and click chemistry respectively. The integration of peptide and Cu-DOTA grants the modified surface the ability to not only efficiently inhibit bacterial growth, but also catalytically generate NO from endogenous s-nitrosothiols (RSNO) to reduce adhesion and activation of platelets, preventing the formation of thrombus. We envision that the stepwise synergistic modification strategy by using anticoagulant NO and antibacterial peptide would facilitate the surface multifunctional engineering of extracorporeal circuits and indwelling medical devices, with reduced clinical complications associated with thrombosis and infection.
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