期刊
BIOACTIVE MATERIALS
卷 6, 期 9, 页码 2783-2800出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.01.040
关键词
Bioactive NF membrane; Diabetic wound healing; Antibacterial; Antioxidant; Anti-inflammatory; Angiogenesis
资金
- Fundamental Research Funds for the Central Universities [2232019A3-07]
- National Key Research Program of China [2016YFC1100202]
- National Natural Science Foundation of China [31771023]
- Science and Technology Commission of Shanghai Municipality [19441902600, 20S31900900]
A multifunctional composite nanofibrous membrane loaded with zinc oxide nanoparticles and oregano essential oil was successfully fabricated with strong in vitro antibacterial and antioxidant activities. The bioactive nanofibrous membrane showed potential in promoting angiogenesis, downregulating pro-inflammatory cytokines, and facilitating wound healing.
Diabetic wound (DW) healing is a major clinical challenge due to multifactorial complications leading to prolonged inflammation. Electrospun nanofibrous (NF) membranes, due to special structural features, are promising biomaterials capable to promote DW healing through the delivery of active agents in a controlled manner. Herein, we report a multifunctional composite NF membrane loaded with ZnO nanoparticles (NP) and oregano essential oil (OEO), employing a new loading strategy, capable to sustainedly co-deliver bioactive agents. Physicochemical characterization revealed the successful fabrication of loaded nanofibers with strong in vitro anti-bacterial and anti-oxidant activities. Furthermore, in vivo wound healing confirmed the potential of bioactive NF membranes in epithelialization and granulation tissue formation. The angiogenesis was greatly prompted by the bioactive NF membranes through expression of vascular endothelial growth factor (VEGF). Moreover, the proposed NF membrane successfully terminated the inflammatory cycle by downregulating the pro-inflammatory cytokines interleukin -6 (IL-6) and matrix metalloproteinases-9 (MMP-9). In vitro and in vivo studies revealed the proposed NF membrane is a promising dressing material for the healing of DW.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据