期刊
BIOACTIVE MATERIALS
卷 6, 期 7, 页码 1910-1920出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.12.006
关键词
Burn wound healing; Hair follicle regeneration; Zn2+ and SiO32-; Sandwich-structured wound dressing; Janus membrane
资金
- National Key Research and Development Program of China [2016YFC1100201]
- National Natural Science Foundation of China [81671830]
- Science and Technology Commission of Shanghai Municipality [19441902300]
A sandwich-structured wound dressing with Janus membrane property was fabricated, showing excellent exudate absorption and bioactivity for promoting hair follicle regeneration and wound healing through the synergistic effect of Zn2+ and SiO32- ions.
The deep burn skin injures usually severely damage the dermis with the loss of hair follicle loss, which are difficult to regenerate. Furthermore, severe burns often accompanied with large amount of wound exudates making the wound moist, easily infected, and difficult to heal. Therefore, it is of great clinical significance to develop wound dressings to remove wound exudates and promote hair follicle regeneration. In this study, a sandwich-structured wound dressing (SWD) with Janus membrane property was fabricated by hot compression molding using hydrophilic zinc silicate bioceramics (Hardystonite, ZnCS) and hydrophobic polylactic acid (PLA). This unique organic/inorganic Janus membrane structure revealed excellent exudate absorption property and effectively created a dry wound environment. Meanwhile, the incorporation of ZnCS bioceramic particles endowed the dressing with the bioactivity to promote hair follicle regeneration and wound healing through the release of Zn2+ and SiO32- ions, and this bioactivity of the wound dressing is mainly attributed to the synergistic effect of Zn2+ and SiO32- to promote the recruitment, viability, and differentiation of hair follicle cells. Our study demonstrates that the utilization of the Janus membrane and synergistic effect of different type bioactive ions are effective approaches for the design of wound dressings for burn wound healing.
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