期刊
CIRCULATION-GENOMIC AND PRECISION MEDICINE
卷 14, 期 4, 页码 517-525出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCGEN.121.003330
关键词
amino acids; cardiovascular diseases; dyslipidemia; inflammation; lipid metabolism
资金
- Brigham and Women's Hospital Department of Medicine
- Uehara Memorial Foundation
- National Institutes of Health (NIH) [CA047988, HL-043851, HL-080467, HL-099355, UM1 CA182913]
- National Heart, Lung, and Blood Institute (NHLBI) [R01HL134811, R01117861, K24 HL136852]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK112940]
- American Heart Association [0670007N]
- Molino Family Trust
- Kowa
- Novartis
- Amarin
- NHLBI
The study found that higher plasma BCAA concentrations are associated with adverse profiles of biomarkers of inflammation and dyslipidemia, reflecting poorer cardiometabolic health.
BACKGROUND: Branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) correlate with insulin resistance and poor glucose control, which may in part explain associations between type 2 diabetes and cardiovascular disease. However, the relationships of BCAAs with other cardiometabolic pathways, including inflammation and dyslipidemia, are unclear. We hypothesized that plasma BCAAs would correlate with multiple pathways of cardiometabolic dysfunction. METHODS: We conducted a cross-sectional analysis among 19472 participants (mean age=54.9 years, SD=7.2 years) in the Women's Health Study without a history of type 2 diabetes, cardiovascular disease, or cancer. We quantified the concentrations of individual biomarkers of inflammation and lipids, across quartiles of BCAAs, adjusting for age, smoking, body mass index, physical activity, and other established cardiovascular disease risk factors at blood draw. RESULTS: Women in the highest versus lowest quartiles of plasma BCAAs had higher inflammatory markers including highsensitivity C-reactive protein (multivariable-adjusted means: 1.96 versus 1.43 mg/L), fibrinogen (367 versus 362 mg/dL), soluble intercellular cell adhesion molecule-1 (361 versus 353 ng/mL), and glycoprotein acetylation (407 versus 371 mu mol/L; P trend=0.0002 for fibrinogen; FQ.0001 for others). Similarly for lipids, women with higher BCAAs had lower HDL-C (high-density lipoprotein cholesterol; 49.0 versus 55.0 mg/dL), and higher triglycerides (143 versus 114 mg/dL), LDL-C (low-density lipoprotein cholesterol; 133 versus 124 mg/dL), and lipoprotein insulin resistance score (52.6 versus 37.3; all: P 1 0.0001). Similar associations with these biomarkers were observed in isoleucine, leucine, and valine, respectively. CONCLUSIONS: Higher circulating BCAA concentrations are associated with adverse profiles of biomarkers of inflammation and dyslipidemia independent of established cardiovascular disease risk factors, and thus, may reflect poorer cardiometabolic health through multiple pathways.
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